Eberconazole
Eberconazole is a dichlorinated imidazole derivative with antifungal activity. Eberconazole is more effective than Clotrimazole (HY-10882), Ketoconazole (HY-B0105), and Miconazole (HY-B0454). Eberconazole has potential for the study of dermatophytosis.
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- CAS No.: 128326-82-9
- Formule: C18H14Cl2N2
- Masse moléculaire:329.22
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Activité biologique
Description
In Vitro
Eberconazole (0.03-2 μg/mL, 7 days) exhibits significant antifungal activity against 200 strains of dermatophytes, with the strongest activity against Trichophyton rubrum and Trichophyton mentagrophytes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Experimentally induced cutaneous candidiasis guinea pig model[2]
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Dosage:1%-1.3% Eberconazole cream, approximately 1-1.3 g per animal
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Administration:Topical application, twice daily, for 6 days
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Result:Caused 90% of guinea pigs clinically recovered and lesions disappeared.
Chemical Information
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CAS No. 128326-82-9
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Masse moléculaire 329.22
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Formule C18H14Cl2N2
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SMILES
ClC1=CC(CCC2=C(C3N4C=NC=C4)C=CC=C2)=C3C(Cl)=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)