Glycosidase

Related Products

Glycosidase are a class of enzymes which catalyze the hydrolysis of glycosidic bonds. In living organisms, Glycosidase are involved in carbohydrate metabolism. They can degrade polysaccharides such as starch and glycogen into monosaccharides, providing energy for cells. Glycosidase also participate in the synthesis and modification of biological macromolecules such as glycoproteins and glycolipids, playing a crucial role in cell recognition and signal transduction. Additionally, in plants and microorganisms, Glycosidase are involved in the metabolism of cell wall polysaccharide components, affecting cell growth, differentiation, and morphogenesis. Gene mutations of Glycosidase can trigger genetic diseases, leading to abnormal metabolism in the body and damage to organ functions. Changes in their activity are associated with various diseases such as diabetes, infectious diseases, and tumors, and can influence the occurrence and development of diseases^[1]^[2].

References:

[1]. Wang X, et al. Metabolites extracted from microorganisms as potential inhibitors of glycosidases (α-glucosidase and α-amylase): A review. Front Microbiol. 2022 Nov 17;13:1050869.

[2]. Ohtsubo K, et al. Glycosylation in cellular mechanisms of health and disease. Cell. 2006 Sep 8;126(5):855-67. [Content Brief]

Glycosidase Related Products (605)
Antibodies (3)

By Effects:	Inhibitors (419) Degraders (2) Controls (4) Substrates (18) Ligands (3) Antagonist (1) Activators (18) Modulators (7) Chemical (1) Inducers (2)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-179698

α-Glucosidase-IN-105	Inhibitor
α-Glucosidase-IN-105 is a selective and potent α-Glucosidase inhibitor with an IC₅₀ of 31.36 μM. α-Glucosidase-IN-105 also inhibits α-Amylase (IC₅₀ = 104.2 μM). α-Glucosidase-IN-105 exhibits inhibitory effects comparable to the standard drug \rAcarbose (HY-B0089). α-Glucosidase-IN-105 can be used for the research of type 2 diabetes.

HY-148575

α-Glucosidase-IN-23	Inhibitor	98.37%
α-Glucosidase-IN-23 is an orally active α-Glucosidase inhibitor. α-Glucosidase-IN-23 decreases blood glucose by a-glucosidase inhibition with an IC₅₀ value of 4.48 μM. α-Glucosidase-IN-23 can be used for the research of diabetes.

HY-159491

DPP-4-IN-11	Inhibitor
DPP-4-IN-11 (compound 10) is an orally active DPP-4 inhibitor (IC₅₀=2.75 μM) with anti-type 2 diabetes activity. DPP-4-IN-11 exerts its glucose-lowering effect by inhibiting the activities of α-glucosidase (IC₅₀=3.02 μM) and α-amylase (IC₅₀=3.3 μM).

HY-145678

α-HNJNAc	Inhibitor
α-HNJNAc is a potent, competitive hexosaminidases inhibitor without interfering with other glycosidases.

HY-N12689

α-Glucosidase-IN-56	Inhibitor
α-Glucosidase-IN-56 (compound 1) is an orally active, potent α‐glucosidase inhibitor with an IC₅₀ value of 45.86 μM. α-Glucosidase-IN-56 has potent anti-glycation activities.

HY-162634

α-Amylase/α-Glucosidase-IN-15	Inhibitor
α-Amylase/α-Glucosidase-IN-15 (compound 6C) is an oral bioactive inhibitor of α-Glucosidase and α-amylase, with the IC₅₀s of 21 μM and 61 μM, respectively.

HY-P2858A

β-Mannosidase, Cellvibrio mixtus
β-Mannosidase, Cellvibrio mixtus (EC 3.2.1.25), is the final exoglycosidase in the N-linked glycoprotein oligosaccharide catabolism pathway. β-Mannosidase catalyzes the following chemical reaction: hydrolysis of the terminal non-reducing β-D-mannose residue in β-D-mannoside.

HY-E70889A

β-Xylosidase, Opitutus terrae
β-Xylosidase, Opitutus terrae (EC 3.2.1.37) can release reducing sugars from birch xylan and catalyze the hydrolysis of 4-methylumbelliferone-β-D-cellobiose and 4-methylumbelliferone-β-D-glucopyranoside. β-Xylosidase does not possess endoxylanase, arabinoxylanase, or β-glucanase activity. β-Xylosidase undergoes post-translational glycosylation modification.

HY-E71305J

β-Glucosidase 1A, Thermotoga petrophila
β-Glucosidase 1A, Thermotoga petrophila (EC 3.2.1.21) is a glucosidase enzyme that acts upon β1->4 bonds linking two glucose or glucose-substituted molecules (i.e., the disaccharide cellobiose) . β-Glucosidase is one of the cellulases, enzymes involved in the decomposition of cellulose and related polysaccharides; more specifically, an exocellulase with specificity for a variety of beta-D-glycoside substrates. It catalyzes the hydrolysis of terminal non-reducing residues in beta-D-glucosides with release of glucose.

HY-150960

α-Glucosidase-IN-13	Inhibitor
α-Glucosidase-IN-13 (Compound 8) is a α-glucosidase inhibitor with an IC₅₀ of 5.69 μM.

HY-175494

α-Glucosidase-IN-96	Inhibitor
α-Glucosidase-IN-96 (Compounds 7b) is a potent α-Glucosidase inhibitor with IC₅₀ values of 9.23 ~ 9.61 μM. α-Glucosidase-IN-96 can be used in diabetes research.

HY-172138

α-Glucosidase-IN-84	Inhibitor
α-Glucosidase-IN-84 (Compound 7j) is a competitive α-glucosidase inhibitor with an IC₅₀ of 50 μM and a K_i of 32 μM. α-Glucosidase-IN-84 holds potential for use in the field of metabolic diseases, such as the study of type 2 diabetes.

HY-155105

α-Glucosidase-IN-30	Inhibitor
α-Glucosidase-IN-30 (compound 8c) is a potent, orally active, competitive inhibitor against α-glucosidase, with K_i of 40.0 µM and IC₅₀ value of 49.0 µM. α-Glucosidase-IN-30 is non-cytotoxic against the cancer and normal cell lines MCF-7 and HDF, and can be used for Type 2 diabetes study.

HY-D3186

HMRef-βGal
HMRef-βGal is a fluorescent probe and a substrate responsive to β-galactosidase (β-galactosidase) (Ex/Em=498 nm/505-600 nm). After being cleaved by β-galactosidase, HMRef-βGal triggers significant fluorescence enhancement via intramolecular spirocyclic function regulation. HMRef-βGal generates bright fluorescence in cancer cells with elevated β-galactosidase activity, enabling visualization of tiny peritoneal metastases in mouse models. HMRef-βGal exhibits low in vitro cytotoxicity and low acute in vivo toxicity in mice. HMRef-βGal can be used for preclinical fluorescence-guided diagnosis and cytoreductive surgery of peritoneal metastases, including compatibility with real-time naked-eye detection and endoscopic imaging, as well as for studies related to peritoneal metastases of ovarian cancer.

HY-163066

α-Glucosidase-IN-44	Inhibitor
α-Glucosidase-IN-44 (compound IT4) is an inhibitor of α-glucosidase with IC₅₀ value of 2.35 μM. α-Glucosidase-IN-44 has an oral activity. α-Glucosidase-IN-44 suppresses fasting blood glucose levels in diabetic mice.

HY-179115

CHI3L1 binder 1	Ligand
CHI3L1 binder 1 (Compound A9) is a CHI3L1 binder with a K_d of 182 µM. CHI3L1 binder 1 can be used in the research of immunity, tissue remodeling, and cancer.

HY-179092

α-Glucosidase-IN-100	Inhibitor
α-Glucosidase-IN-100 (compound 6) is a potent alpha glucosidase inhibitor. α-Glucosidase-IN-100 can be used to study metabolic diseases such as diabetes.

HY-131504A

Valienamine	Inhibitor
Valienamine is the alpha-glucosidase inhibitor. Valienamine is the key functional component of many natural glycosidase inhibitors including the crop protectant validamycin A and the antidiabetic agent acarbose.

HY-179487

α-Glucosidase-IN-102	Inhibitor
α-Glucosidase-IN-102 (Compound 8e) is a competitive inhibitor of α-glucosidase with an IC₅₀ value of 36.2 μM. α-Glucosidase-IN-102 can be used for research on diabetes.

HY-N16529

1,6,8-Trihydroxy-2,7-dimethoxy-3-methylanthraquinone	Inhibitor
1,6,8-Trihydroxy-2,7-dimethoxy-3-methylanthraquinone (Compound 2) is a anthraquinone aglycone found in Cassia obtusefolia. 1,6,8-Trihydroxy-2,7-dimethoxy-3-methylanthraquinone can inhibit α-glucosidase with an IC₅₀ of 120.65 μg/mL. 1,6,8-Trihydroxy-2,7-dimethoxy-3-methylanthraquinone can be used for the research of diabetes.

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Glycosidase

Glycosidase

Glycosidase Related Products (605)

Antibodies (3)

Glycosidase Related Products (605):