2. Signaling Pathways
  3. GPCR/G Protein
    Immunology/Inflammation
    Neuronal Signaling
  4. Histamine Receptor
  5. H3 Receptor Isoform
  6. H3 Receptor Antagonist

H3 Receptor Antagonist

H3 Receptor Antagonists (15):

Cat. No. Product Name Effect Purity
  • HY-14880B
    Bavisant dihydrochloride hydrate
    		Antagonist 99.60%
    Bavisant dihydrochloride hydrate (JNJ31001074AAC) is an orally active, potent, brain-penetrating and highly selective antagonist of the histamine H3 receptor.
  • HY-12195
    ABT-239
    		Antagonist 98.49%
    ABT-239 is a novel, highly efficacious, non-imidazole class of H3R antagonist and a transient receptor potential vanilloid type 1 (TRPV1) antagonist.
  • HY-U00076
    MK-0249
    		Antagonist 99.53%
    MK-0249 (Compound 1) is a potent, selective and orally active histamine H3 receptor antagonist, with an IC50 of 1.7 nM for human H3.
  • HY-107558
    JNJ10191584 maleate
    		Antagonist
    JNJ10191584 (VUF6002) maleate (compound 40) is an orally active and selective histamine H4 receptor antagonist with a Ki value of 26 nM.
  • HY-123532
    JNJ10191584
    		Antagonist
    JNJ10191584 (VUF6002) is an orally active and selective histamine H4 receptor antagonist with a Ki value of 26 nM.
  • HY-115447
    Clobenpropit
    		Antagonist
    Clobenpropit is a potent histamine H3-receptor antagonist.
  • HY-12190
    JNJ-5207852
    		Antagonist ≥98.0%
    JNJ-5207852 is a selective and potent histamine H3 receptor (H3R) antagonist, with pKis of 8.9, 9.24 for rat and human H3R, respectively.
  • HY-107566
    Conessine
    		Antagonist ≥98.0%
    Conessine, a steroidal alkaloid, is a potent and selective histamine H3 receptor antagonist with Kis of 5.4, 6.0, 5.7 and 25 nM for human, dog, guinea pig, and rat H H3 receptor, respectively.
  • HY-14880
    Bavisant
    		Antagonist
    Bavisant (JNJ-31001074) is an orally active, potent, brain-penetrating and highly selective antagonist of the histamine H3 receptor.
  • HY-12190A
    JNJ-5207852 dihydrochloride
    		Antagonist
    JNJ-5207852 dihydrochloride is a selective and potent histamine H3 receptor (H3R) antagonist, with pKis of 8.9, 9.24 for rat and human H3R, respectively.
  • HY-109968A
    Irdabisant hydrochloride
    		Antagonist
    Irdabisant (CEP-26401) hydrochloride is a selective, orally active and blood-brain barrier (BBB) penetrant histamine H3 receptor (H3R) inverse agonist/inverse agonist with Ki values of 7.2 nM and 2.0 nM for rat H3R and human H3R, respectively.
  • HY-12206A
    Thioperamide maleate
    		Antagonist
    Thioperamide maleate (MR-12842 maleate) is a potent, orally available, brain penetrant and selective H3 receptor antagonist with a Ki of 4.3 nM for inhibition of [3H]histamine release.
  • HY-109968
    Irdabisant
    		Antagonist
    Irdabisant (CEP-26401) is a selective, orally active and blood-brain barrier (BBB) penetrant histamine H3 receptor (H3R) inverse agonist/inverse agonist with Ki values of 7.2 nM and 2.0 nM for rat H3R and human H3R, respectively.
  • HY-146383
    H3R antagonist 2
    		Antagonist
    H3R antagonist 2 (Compound 23) is a multitarget histamine H3 receptor (H3R) antagonist with a Ki of 170 nM for hH3R .
  • HY-14880A
    Bavisant dihydrochloride
    		Antagonist
    Bavisant (JNJ-31001074) dihydrochloride is an orally active, potent, brain-penetrating and highly selective antagonist of the histamine H3 receptor.