1. GPCR/G Protein
    Immunology/Inflammation
  2. Histamine Receptor

Ciproxifan maleate (Synonyms: FUB 359 maleate)

Cat. No.: HY-15289 Purity: 99.56%
Handling Instructions

Ciproxifan maleate(FUB-359 maleate) is a highly potent and selective histamin H3-receptor antagonist with IC50 of 9.2 nM, with low apparent affinity at other receptor subtypes.

For research use only. We do not sell to patients.

Ciproxifan maleate Chemical Structure

Ciproxifan maleate Chemical Structure

CAS No. : 184025-19-2

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 106 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
5 mg USD 96 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
10 mg USD 144 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
50 mg USD 480 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Other Forms of Ciproxifan maleate:

  • Biological Activity

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  • References

Description

Ciproxifan maleate(FUB-359 maleate) is a highly potent and selective histamin H3-receptor antagonist with IC50 of 9.2 nM, with low apparent affinity at other receptor subtypes. IC50 value: Target: H3 receptor In vitro, Ciproxifan behaved as a competitive antagonist at the H3 autoreceptor controlling 3H histamine release from synaptosomes and displayed similar Ki values (0.5-1.9 nM) at the H3 receptor controlling the electrically-induced contraction of guinea pig ileum or at the brain H3 receptor labeled with 125I-iodoproxyfan. This appears to be an orally bioavailable, extremely selective and potent H3-receptor antagonist whose vigilance- and attention-promoting effects are promising for therapeutic applications in aging disorders.

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5880 mL 12.9400 mL 25.8799 mL
5 mM 0.5176 mL 2.5880 mL 5.1760 mL
10 mM 0.2588 mL 1.2940 mL 2.5880 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

386.40

Formula

C₂₀H₂₂N₂O₆

CAS No.

184025-19-2

SMILES

O=C(C1CC1)C2=CC=C(OCCCC3=CNC=N3)C=C2.O=C(O)/C=C\C(O)=O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Ciproxifan maleate
Cat. No.:
HY-15289
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Ciproxifan maleate

Cat. No.: HY-15289