1. GPCR/G Protein
    Immunology/Inflammation
  2. Histamine Receptor

Ciproxifan maleate (Synonyms: FUB 359 maleate)

Cat. No.: HY-15289 Purity: 99.56%
Data Sheet SDS Handling Instructions

Ciproxifan maleate(FUB-359 maleate) is a highly potent and selective histamin H3-receptor antagonist with IC50 of 9.2 nM, with low apparent affinity at other receptor subtypes.

For research use only. We do not sell to patients.
Ciproxifan maleate Chemical Structure

Ciproxifan maleate Chemical Structure

CAS No. : 184025-19-2

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 106 In-stock
5 mg USD 96 In-stock
10 mg USD 144 In-stock
50 mg USD 480 In-stock
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Other Forms of Ciproxifan maleate:

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  • Protocol

  • Technical Information

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  • References

Description

Ciproxifan maleate(FUB-359 maleate) is a highly potent and selective histamin H3-receptor antagonist with IC50 of 9.2 nM, with low apparent affinity at other receptor subtypes. IC50 value: Target: H3 receptor In vitro, Ciproxifan behaved as a competitive antagonist at the H3 autoreceptor controlling 3H histamine release from synaptosomes and displayed similar Ki values (0.5-1.9 nM) at the H3 receptor controlling the electrically-induced contraction of guinea pig ileum or at the brain H3 receptor labeled with 125I-iodoproxyfan. This appears to be an orally bioavailable, extremely selective and potent H3-receptor antagonist whose vigilance- and attention-promoting effects are promising for therapeutic applications in aging disorders.

References
Molecular Weight

386.4

Formula

C₂₀H₂₂N₂O₆

CAS No.

184025-19-2

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Ciproxifan maleate
Cat. No.:
HY-15289
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