184025-19-2
184025-19-2
Chemical Structure
Ciproxifan maleate
Synonym(s): FUB 359 maleate
- CAS No.: 184025-19-2
- Formula:C20H22N2O6
- Molecular Weight:386.40
IUPAC Name: (4-(3-(1H-imidazol-4-yl)propoxy)phenyl)(cyclopropyl)methanone maleate
InChIKey: RLQFKEYRALXXEJ-BTJKTKAUSA-N
SMILES: O=C(C1CC1)C2=CC=C(OCCCC3=CNC=N3)C=C2.O=C(O)/C=C\C(O)=O
Biological Activity: Ciproxifan maleate (FUB 359 maleate) is a potent, selective, orally bioavailable and competitive antagonist of histamine H3-receptor, with an IC50 of 9.2 nM. Ciproxifan maleate displays low apparent affinity at other receptor subtypes. Ciproxifan maleate can be used for the research of aging disorders and Alzheimer's disease[1][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Ciproxifan maleate | 99.68% | Ciproxifan maleate (FUB 359 maleate) is a potent, selective, orally bioavailable and competitive antagonist of histamine H3-receptor, with an IC50 of 9.2 nM. Ciproxifan maleate displays low apparent affinity at other receptor subtypes. Ciproxifan maleate can be used for the research of aging disorders and Alzheimer's disease. | ||||||||||||||||||||
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Ciproxifan maleate (Standard) | ≥98% | Ciproxifan (maleate) (Standard) is the analytical standard of Ciproxifan (maleate). This product is intended for research and analytical applications. Ciproxifan maleate (FUB 359 maleate) is a potent, selective, orally bioavailable and competitive antagonist of histamine H3-receptor, with an IC50 of 9.2 nM. Ciproxifan maleate displays low apparent affinity at other receptor subtypes. Ciproxifan maleate can be used for the research of aging disorders and Alzheimer's disease. | ||||||||||||||||||||
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References
- [1]. Ligneau X, et, al. Neurochemical and behavioral effects of ciproxifan, a potent histamine H3-receptor antagonist. J Pharmacol Exp Ther. 1998 Nov;287(2):658-66. [Content Brief]
- [3]. Bardgett ME, Davis NN, Schultheis PJ, Griffith MS. Ciproxifan, an H3 receptor antagonist, alleviates hyperactivity and cognitive deficits in the APP Tg2576 mouse model of Alzheimer's disease. Neurobiol Learn Mem. 2011 Jan;95(1):64-72. [Content Brief]
