2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Isocitrate Dehydrogenase (IDH)
  5. IDH1 Isoform

IDH1

 

IDH1 Related Products (6):

Cat. No. Product Name Effect Purity
  • HY-18082
    AGI-5198
    		Inhibitor 99.77%
    AGI-5198 (IDH-C35) is a potent and selective mutant IDH1R132H inhibitor with an IC50 of 0.07 μM.
  • HY-12475
    Mutant IDH1-IN-1
    		Inhibitor 99.53%
    Mutant IDH1-IN-1 is a mutant-selective IDH1 inhibitor with with IC50s of 4, 42, 80 and 143 nM against mutant IDH1 R132C/R132C, IDH1 R132H/R132H, IDH1 R132H/WT and wild type IDH1, respectively.
  • HY-128888B
    (S,R)-GSK321
    		Inhibitor 98.78%
    (S,R)-WT IDH1 Inhibitor 2 (GSK321) is a potent, selective mutant IDH1 inhibitor with IC50 values of 2.9, 3.8, 4.6 and 46 nM for R132G, R132C, R132H and WT IDH1, respectively, and >100-fold selectivity over IDH2.
  • HY-128888
    (R,R)-GSK321
    		Inhibitor 99.31%
    (R,R)-GSK321 is a wild-type isocitrate dehydrogenase 1 (WT IDH1) inhibitor with an IC50 value of 120 nM.
  • HY-110144
    TC-E 5008
    		Inhibitor
    TC-E 5008 is a potent mutant IDH1 inhibitor with Ki values of 190 nM and 120 nM for R132H and R132C IDH1 mutants, respectively.
  • HY-150238
    IDH1 Inhibitor 7
    		Inhibitor
    IDH1 Inhibitor 7 (Compound 88) is an IDH1 inhibitor with an IC50 of less than 100 nM.