1. Metabolic Enzyme/Protease
  2. Isocitrate Dehydrogenase (IDH)

Mutant IDH1-IN-2 

Cat. No.: HY-18717 Purity: 97.79%
Handling Instructions

Mutant IDH1-IN-2 is a inhibitor of mutant Isocitrate dehydrogenase (IDH) proteins, with IC50 of in LS-MS biochemical assay, IC50 of 16.6 nM in Fluorescence biochemical assay.

For research use only. We do not sell to patients.

Mutant IDH1-IN-2 Chemical Structure

Mutant IDH1-IN-2 Chemical Structure

CAS No. : 1429176-69-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 462 In-stock
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

    Mutant IDH1-IN-2 purchased from MCE. Usage Cited in: Sci Rep. 2017 Oct 6;7(1):12758.

    Represented western blot of an isothermal dose-response at melting temperature of 59°C demonstrating cellular mIDH1 enzyme thermal stabilization with mIDH1 inhibitors.
    • Biological Activity

    • Technical Information

    • Purity & Documentation

    • References

    Description

    Mutant IDH1-IN-2 is a inhibitor of mutant Isocitrate dehydrogenase (IDH) proteins, with IC50 of in LS-MS biochemical assay, IC50 of 16.6 nM in Fluorescence biochemical assay. Target: Mutant IDH1 Mutant IDH1-IN-2 has a neomorphic activity and in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer. More bioactivity information in Patent WO 2013046136A1 (Example 224).

    Solvent & Solubility
    In Vitro: 

    10 mM in DMSO

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.1761 mL 10.8807 mL 21.7614 mL
    5 mM 0.4352 mL 2.1761 mL 4.3523 mL
    10 mM 0.2176 mL 1.0881 mL 2.1761 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
    Molecular Weight

    459.53

    Formula

    C₂₄H₃₁F₂N₅O₂

    CAS No.

    1429176-69-1

    SMILES

    O=C1OC[[email protected]](C(C)C)N1C2=NC(N[[email protected]](C3=CC=C(CN4CCC(F)(F)CC4)C=C3)C)=NC=C2

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Shipping

    Room temperature in continental US; may vary elsewhere

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    × = ×
    C1   V1   C2   V2

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    Product Name:
    Mutant IDH1-IN-2
    Cat. No.:
    HY-18717
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    Mutant IDH1-IN-2

    Cat. No.: HY-18717