1. Metabolic Enzyme/Protease
  2. Isocitrate Dehydrogenase (IDH)

Mutant IDH1-IN-2 

Cat. No.: HY-18717
Handling Instructions

Mutant IDH1-IN-2 is a inhibitor of mutant Isocitrate dehydrogenase (IDH) proteins, with IC50 of in LS-MS biochemical assay, IC50 of 16.6 nM in Fluorescence biochemical assay.

For research use only. We do not sell to patients.
Mutant IDH1-IN-2 Chemical Structure

Mutant IDH1-IN-2 Chemical Structure

CAS No. : 1429176-69-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 462 In-stock
5 mg USD 420 In-stock
10 mg USD 600 In-stock
50 mg USD 1800 In-stock
100 mg   Get quote  
200 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • References

Description

Mutant IDH1-IN-2 is a inhibitor of mutant Isocitrate dehydrogenase (IDH) proteins, with IC50 of in LS-MS biochemical assay, IC50 of 16.6 nM in Fluorescence biochemical assay. Target: Mutant IDH1 Mutant IDH1-IN-2 has a neomorphic activity and in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer. More bioactivity information in Patent WO 2013046136A1 (Example 224).

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.1761 mL 10.8807 mL 21.7614 mL
5 mM 0.4352 mL 2.1761 mL 4.3523 mL
10 mM 0.2176 mL 1.0881 mL 2.1761 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

459.53

Formula

C₂₄H₃₁F₂N₅O₂

CAS No.

1429176-69-1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Mutant IDH1-IN-2
Cat. No.:
HY-18717
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