1. Metabolic Enzyme/Protease
  2. Isocitrate Dehydrogenase (IDH)

Vorasidenib (Synonyms: AG-881)

Cat. No.: HY-104042 Purity: 99.38%
Handling Instructions

Vorasidenib is a pan isocitrate dehydrogenase (IDH) inhibitor.

For research use only. We do not sell to patients.

Vorasidenib Chemical Structure

Vorasidenib Chemical Structure

CAS No. : 1644545-52-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 208 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
2 mg USD 132 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
5 mg USD 228 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
10 mg USD 348 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
50 mg USD 1068 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
100 mg USD 1440 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Vorasidenib is a pan isocitrate dehydrogenase (IDH) inhibitor.

IC50 & Target

IDH[1]

In Vitro

Vorasidenib has recently entered phase 1 clinical trials in hematologic (NCT02492737) and solid malignancies (NCT02481154) in patients with either an IDH1 or an IDH2 mutation. Preclinical studies have suggested that Vorasidenib fully penetrates the blood-brain barrier and may be a more effective option for patients with IDH1/2 mutated glioma[1].

Clinical Trial
References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.4111 mL 12.0557 mL 24.1115 mL
5 mM 0.4822 mL 2.4111 mL 4.8223 mL
10 mM 0.2411 mL 1.2056 mL 2.4111 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

414.74

Formula

C₁₄H₁₃ClF₆N₆

CAS No.

1644545-52-7

SMILES

C[[email protected]@H](NC1=NC(C2=NC(Cl)=CC=C2)=NC(N[[email protected]](C)C(F)(F)F)=N1)C(F)(F)F

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Vorasidenib
Cat. No.:
HY-104042
Quantity: