1. Metabolic Enzyme/Protease
  2. Isocitrate Dehydrogenase (IDH)
  3. Olutasidenib

Olutasidenib (Synonyms: FT-2102)

Cat. No.: HY-114226 Purity: 98.35%
Handling Instructions

Olutasidenib is a highly potent, selective inhibitor of mutant Isocitrate dehydrogenase 1 (IDH1) that could be used in the treatment of acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS).

For research use only. We do not sell to patients.

Olutasidenib Chemical Structure

Olutasidenib Chemical Structure

CAS No. : 1887014-12-1

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 275 In-stock
Estimated Time of Arrival: December 31
5 mg USD 250 In-stock
Estimated Time of Arrival: December 31
10 mg USD 350 In-stock
Estimated Time of Arrival: December 31
25 mg USD 700 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1100 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Olutasidenib is a highly potent, selective inhibitor of mutant Isocitrate dehydrogenase 1 (IDH1) that could be used in the treatment of acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS).

IC50 & Target

IDH1[1].

Clinical Trial
Molecular Weight

354.79

Formula

C₁₈H₁₅ClN₄O₂

CAS No.

1887014-12-1

SMILES

N#CC1=CC=C(N[[email protected]](C2=CC3=C(NC2=O)C=CC(Cl)=C3)C)C(N1C)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (352.32 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8186 mL 14.0928 mL 28.1857 mL
5 mM 0.5637 mL 2.8186 mL 5.6371 mL
10 mM 0.2819 mL 1.4093 mL 2.8186 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.86 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.86 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Product Name:
Olutasidenib
Cat. No.:
HY-114226
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