1. Metabolic Enzyme/Protease
  2. Isocitrate Dehydrogenase (IDH)

IDH-305 

Cat. No.: HY-104036 Purity: 98.01%
Handling Instructions

IDH-305 is an inhibitor of isocitrate dehydrogenase (IDH).

For research use only. We do not sell to patients.

IDH-305 Chemical Structure

IDH-305 Chemical Structure

CAS No. : 1628805-46-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 363 In-stock
Estimated Time of Arrival: December 31
1 mg USD 132 In-stock
Estimated Time of Arrival: December 31
5 mg USD 336 In-stock
Estimated Time of Arrival: December 31
10 mg USD 576 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1440 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2280 In-stock
Estimated Time of Arrival: December 31
200 mg USD 3480 In-stock
Estimated Time of Arrival: December 31
500 mg   Get quote  
1 g   Get quote  

* Please select Quantity before adding items.

Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

IDH-305 is an inhibitor of isocitrate dehydrogenase (IDH).

IC50 & Target

IDH[1]

In Vitro

IDH-305 is an inhibitor of isocitrate dehydrogenase (IDH). Isocitrate dehydrogenase (IDH) is an essential enzyme for cellular respiration in the tricarboxylic acid (TCA) cycle. The IDH1 inhibitor IDH-305 has entered an ongoing phase 1 clinical trial (NCT02381886) for patients with IDH1-R132 mutant advanced hematologic or solid malignancies[1].

Clinical Trial
Solvent & Solubility
In Vitro: 

DMSO : ≥ 150 mg/mL (305.84 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0389 mL 10.1947 mL 20.3894 mL
5 mM 0.4078 mL 2.0389 mL 4.0779 mL
10 mM 0.2039 mL 1.0195 mL 2.0389 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

490.45

Formula

C₂₃H₂₂F₄N₆O₂

CAS No.

1628805-46-8

SMILES

O=C1OC[[email protected]]([[email protected]@H](F)C)N1C2=NC(N[[email protected]](C3=CC(C)=C(C4=CC(C(F)(F)F)=NC=C4)C=N3)C)=NC=C2

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Purity: 98.01%

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Inquiry Information

Product Name:
IDH-305
Cat. No.:
HY-104036
Quantity:

IDH-305

Cat. No.: HY-104036