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Cat. No.: HY-104036R

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IDH-305 (Standard)

IDH-305 (Standard) is the analytical standard of IDH-305 (HY-104036). This product is intended for research and analytical applications. IDH-305 is an orally available, mutant-selective and brain-penetrant IDH1 inhibitor that targets IDH1 (R132) mutation. IDH-305 exhibits greater than 200 fold selectivity for mutant IDH1 isoforms vs. WT (IC₅₀= 27 nM (IDH1R132H), 28 nM (IDH1R132C), 6.14 µM (IDH1WT)).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 1628805-46-8
화학식: C₂₃H₂₂F₄N₆O₂
분자량:490.45

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

IDH-305 (Standard) Chemical Structure

CAS No.: 1628805-46-8

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Product Information

Information

신청

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 1628805-46-8
분자량 490.45
화학식 C₂₃H₂₂F₄N₆O₂
SMILES

O=C1OC[C@H]([C@@H](F)C)N1C2=NC(N[C@H](C3=CC(C)=C(C4=CC(C(F)(F)F)=NC=C4)C=N3)C)=NC=C2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Cho YS, et al. Discovery and Evaluation of Clinical Candidate IDH305, a Brain Penetrant Mutant IDH1 Inhibitor. ACS Med Chem Lett. 2017 Sep 18;8(10):1116-1121. [Content Brief]

[2]. Courtney D DiNardo, et al. A Phase I Study of IDH305 in Patients with Advanced Malignancies Including Relapsed/Refractory AML and MDS That Harbor IDH1R132 Mutations. Blood, 128(22), 1073.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Product Information
- Information
- 신청
Chemical Information
순도&문서

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

IDH-305 (Standard)

IDH-305

Ivosidenib

Vorasidenib

Enasidenib

AGI-5198

AGI-6780

Olutasidenib

DS-1001b

GSK864

BAY-1436032

Enasidenib mesylate

Mutant IDH1-IN-1

Product Information

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Bioz

IDH-305 (Standard)

IDH-305

Ivosidenib

Vorasidenib

Enasidenib

AGI-5198

AGI-6780

Olutasidenib

DS-1001b

GSK864

BAY-1436032

Enasidenib mesylate

Mutant IDH1-IN-1

Product Information

Chemical Information

순도&문서

References

Calculators

Help & FAQs

IDH-305 (Standard) Related Classifications

HY-104036R Related Classifications

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