1. Metabolic Enzyme/Protease
  2. Isocitrate Dehydrogenase (IDH)
  3. DS-1001b

DS-1001b 

Cat. No.: HY-129545 Purity: 98.90%
Handling Instructions

DS-1001b is a mutant IDH-1 (Isocitrate Dehydrogenase-1) inhibitor extracted from patent WO2016052697A1, Example 168, and has antitumor activity.

For research use only. We do not sell to patients.

DS-1001b Chemical Structure

DS-1001b Chemical Structure

CAS No. : 1898207-64-1

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 288 In-stock
Estimated Time of Arrival: December 31
5 mg USD 215 In-stock
Estimated Time of Arrival: December 31
10 mg USD 365 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1095 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

DS-1001b is a mutant IDH-1 (Isocitrate Dehydrogenase-1) inhibitor extracted from patent WO2016052697A1, Example 168, and has antitumor activity[1].

IC50 & Target

IDH-1[1]

Clinical Trial
Molecular Weight

608.92

Formula

C₂₉H₂₉Cl₃FN₃O₄

CAS No.

1898207-64-1

SMILES

CC(C)(N)C.O=C(N1C2=CC=CC(/C=C/C(O)=O)=C2C(C)=C1)C3=C(C(C)(F)C)ON=C3C4=C(C=C(Cl)C=C4Cl)Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 29 mg/mL (47.63 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6423 mL 8.2113 mL 16.4225 mL
5 mM 0.3285 mL 1.6423 mL 3.2845 mL
10 mM 0.1642 mL 0.8211 mL 1.6423 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.42 mg/mL (3.97 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.42 mg/mL (3.97 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.90%

  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

DS-1001bIsocitrate Dehydrogenase (IDH)Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product name:
DS-1001b
Cat. No.:
HY-129545
Quantity:
MCE Japan Authorized Agent: