1. Metabolic Enzyme/Protease
  2. Isocitrate Dehydrogenase (IDH)

Mutant IDH1-IN-1 

Cat. No.: HY-12475
Handling Instructions

Mutant IDH1-IN-1 is a mutant-selective IDH1 inhibitor with with IC50s of 4, 42, 80 and 143 nM against mutant IDH1 R132C/R132C, IDH1 R132H/R132H, IDH1 R132H/WT and wild type IDH1, respectively.

For research use only. We do not sell to patients.

Mutant IDH1-IN-1 Chemical Structure

Mutant IDH1-IN-1 Chemical Structure

CAS No. : 1355326-21-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 462 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
50 mg USD 1800 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
100 mg USD 2520 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • References

Description

Mutant IDH1-IN-1 is a mutant-selective IDH1 inhibitor with with IC50s of 4, 42, 80 and 143 nM against mutant IDH1 R132C/R132C, IDH1 R132H/R132H, IDH1 R132H/WT and wild type IDH1, respectively.

IC50 & Target

IC50: 4 nM (IDH1 R132C/R132C), 42 nM (IDH1 R132H/R132H), 80 nM (IDH1 R132H/WT), 143 nM (IDH1 wild type)[1]

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.0057 mL 10.0283 mL 20.0566 mL
5 mM 0.4011 mL 2.0057 mL 4.0113 mL
10 mM 0.2006 mL 1.0028 mL 2.0057 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

498.59

Formula

C₃₀H₃₁FN₄O₂

CAS No.

1355326-21-4

SMILES

O=C(C(C1=C(C)C=CC=C1)N(C(CN2C=NC3=C2C=CC=C3)=O)C4=CC(F)=CC=C4)NC5CCCCC5

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 45 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Mutant IDH1-IN-1
Cat. No.:
HY-12475
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