1355326-21-4
Chemical Structure
Mutant IDH1-IN-1
Synonym(s): Agios 135
- CAS No.: 1355326-21-4
- Formula:C30H31FN4O2
- Molecular Weight:498.59
IUPAC Name: 2-(2-(1H-benzo[d]imidazol-1-yl)-N-(3-fluorophenyl)acetamido)-N-cyclohexyl-2-(o-tolyl)acetamide
InChIKey: DXYIOARJXVTYJW-UHFFFAOYSA-N
SMILES: O=C(C(C1=C(C)C=CC=C1)N(C(CN2C=NC3=C2C=CC=C3)=O)C4=CC(F)=CC=C4)NC5CCCCC5
Biological Activity: Mutant IDH1-IN-1 (Agios 135) is a selective mutant IDH1 inhibitor with activity against both IDH1R132H and IDH1R132C. Mutant IDH1-IN-1 reduces the level of 2-hydroxyglutarate (2-HG), stabilizes mutant IDH1 protein, and restores blocked monocyte differentiation. Mutant IDH1-IN-1 can be used in tumor-related research[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Mutant IDH1-IN-1 | 98.78% | Mutant IDH1-IN-1 (Agios 135) is a selective mutant IDH1 inhibitor with activity against both IDH1R132H and IDH1R132C. Mutant IDH1-IN-1 reduces the level of 2-hydroxyglutarate (2-HG), stabilizes mutant IDH1 protein, and restores blocked monocyte differentiation. Mutant IDH1-IN-1 can be used in tumor-related research. | ||||||||||||||||||||
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