2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite

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Endogenous metabolites refer to the collective set of small-molecule chemical substances present within organelles, cells, organs, biological fluids, or entire organisms; their molecular weights are typically less than 1500 Da. These endogenous metabolites—including lipids, amino acids, short peptides, nucleic acids, carbohydrates, alcohols, and organic acids—not only participate in signal transduction governing genomic function but also receive upstream signals from the environment, thereby bridging the interrelationships among genotype, environment, and phenotype. Based on their biological functions, microbial endogenous metabolites can be broadly classified into two categories: primary metabolites and secondary metabolites. Primary metabolites are the core molecules essential for supporting microbial growth and proliferation; they serve to provide energy to the microbes or act as precursors and cofactors for the synthesis of biological macromolecules. In contrast, microbial secondary metabolites are a class of low-molecular-weight products that are not strictly essential for microbial growth. Nevertheless, microbial secondary metabolites include numerous substances—such as antibiotics, anti-tumor agents, and cholesterol-lowering agents—that are of critical importance to human health[1][2][3]. Furthermore, the metabolome of a biological organism is influenced by a variety of endogenous factors, including age, sex, body composition, genetic background, and underlying pathological states. The small-molecule metabolites within an organism are diverse and highly distinct; their levels are typically subject to the synergistic regulation of a vast array of enzymes and transport proteins, undergoing processes of synthesis, transformation, degradation, and compartmentalized distribution. Metabolomics research based on endogenous metabolites has been widely applied in the fields of metabolic disorders, neurodegenerative diseases, cancer, cardiovascular diseases, and infectious diseases, where these metabolites hold potential utility as biomarkers or therapeutic targets[1][2][3].

Endogenous Metabolite Isoform Specific Products:

Endogenous Metabolite Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-113236R
    p-Synephrine (Standard)
    p-Synephrine (Standard) is the analytical standard of p-Synephrine. This product is intended for research and analytical applications. p-Synephrine is an organic compound, found in multiple biofluids, such as urine and blood.
    p-Synephrine (Standard)
  • HY-117012
    NE58018
    NE58018 is a compound with bone resorption inhibitory activity. NE58018 exerts its effect by affecting the action of Farnesyl pyrophosphate synthase (FPPS). The structural features of NE58018 combined with aminophosphonates significantly enhance its inhibitory activity. NE58018 affects the roles of Thr201 and Tyr204 residues in substrate binding and catalysis. The interaction of NE58018 enhances the inhibitory effect on the target enzyme.
    NE58018
  • HY-W014423S1
    L-Histidine-13C6,15N3,d5 hydrochloride hydrate
    L-Histidine-13C6,15N3,d5 hydrochloride hydrate is the deuterium, 13C-, and 15-labeled L-Histidine hydrochloride hydrate (HY-W014423). L-Histidine hydrochloride hydrate is an endogenous metabolite. L-Histidine hydrochloride hydrate scavenges hydroxyl radicals and singlet oxygen, regulate the absorption of zinc, copper and iron, exhibits anti-inflammatory and antioxidant activities. L-Histidine hydrochloride hydrate is blood brain barrier penetrable.
    L-Histidine-<sup>13</sup>C<sub>6</sub>,<sup>15</sup>N<sub>3</sub>,d<sub>5</sub> hydrochloride hydrate
  • HY-164999
    N,N'-Bis(2,3-Dihydroxybenzoyl)-O-L-seryl-L-serine
    N,N'-Bis(2,3-Dihydroxybenzoyl)-O-L-seryl-L-serine is a enterochelin hydrolyzed product. N,N'-Bis(2,3-Dihydroxybenzoyl)-O-L-seryl-L-serine can inhibit the invasion of murine colon cancer cells 26-L5 with an IC50 of 2.7 μM, and has anti-tumor effect. In addition, N,N'-Bis(2,3-Dihydroxybenzoyl)-O-L-seryl-L-serine has no appreciable antimicrobial activities against Micrococcus luteus, Escherichia coli and Candida albicans.
    N,N'-Bis(2,3-Dihydroxybenzoyl)-O-L-seryl-L-serine
  • HY-158626
    10(S)-PAHSA
    10(S)-PAHSA is a stereoisomer of 10-PAHSA, an endogenous lipid that belongs to a collection of branched fatty acid esters of hydroxy fatty acids (FAHFAs).
    10(S)-PAHSA
  • HY-157679
    1-O-Hexadecyl-2-eicosapentaenoyl-SN-glycero-3-phosphocholine
    1-O-Hexadecyl-2-eicosapentaenoyl-SN-glycero-3-phosphocholine is a phospholipid present in blood plasma and blood cells.
    1-O-Hexadecyl-2-eicosapentaenoyl-SN-glycero-3-phosphocholine
  • HY-176105
    (±)6,7-DiHODE(γ)
    (±)6,7-DiHODE(γ), a oxylipin, is a dihydroxyoctadecadienoic acid.
    (±)6,7-DiHODE(γ)
  • HY-113380R
    (S)-β-Aminoisobutyric acid (Standard)
    (S)-β-Aminoisobutyric acid (Standard) is the analytical standard of (S)-β-Aminoisobutyric acid. This product is intended for research and analytical applications. (S)-β-Aminoisobutyric acid is a non-protein amino acid originating from the catabolism of thymine and valine.
    (S)-β-Aminoisobutyric acid (Standard)
  • HY-110189R
    Pregnenolone monosulfate sodium (Standard)
    Pregnenolone monosulfate (sodium) (Standard) is the analytical standard of Pregnenolone monosulfate (sodium). This product is intended for research and analytical applications. Pregnenolone monosulfate sodium (3β-Hydroxy-5-pregnen-20-one monosulfate sodium) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate sodium can protect the brain from cannabis intoxication. Pregnenolone monosulfate sodium is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels.
    Pregnenolone monosulfate sodium (Standard)
  • HY-12539
    Fluorocurarine chloride
    Fluorocurarine chloride (Metvine; Vincanine methyl chloride) is a plant metabolite that can be isolated from Catharanthus roseus.
    Fluorocurarine chloride
  • HY-N7814R
    2-Hydroxypalmitic acid (Standard)
    Pheniramine (maleate) (Standard) is the analytical standard of Pheniramine (maleate). This product is intended for research and analytical applications. Pheniramine (Prophenpyridamine; Tripoton) maleate is a first-generation histamine H1 receptor antagonist, acts on the central nervous system (CNS) with sedative and hypnotic effect. Pheniramine maleate displays antitumor effect and induces leukemia cells apoptosis. Pheniramine maleate is also a safe and effective local agent that can suppress or relieve pain, with antipruritic effects.
    2-Hydroxypalmitic acid (Standard)
  • HY-W654121
    p-Cresol sulfate-d4 potassium
    p-Cresol sulfate-d4 (potassium) is deuterium labeled p-Cresyl sulfate (potassium). p-Cresyl sulfate potassium is a uremic toxin that binds to a prototype protein. p-Cresyl sulfate potassium activates the JNK and p38 MAPK signaling pathways. p-Cresyl sulfate potassium has pro-inflammatory activity.
    p-Cresol sulfate-d<sub>4</sub> potassium
  • HY-W051199
    O-Phosphono-L-homoserine
    O-Phosphono-L-homoserine (o-Phosphohomoserine) is an intermediate in threonine synthesis in bacteria and plants, and can also be hijacked by MetM in some Streptomyces species to enter a novel methionine synthesis pathway. O-Phosphono-L-homoserine acts as a weak antagonist of the NMDA receptor. O-Phosphono-L-homoserine can be used as a substrate for studies on amino acid metabolism of the aspartate family, a control for mechanism studies of PLP enzymes, and a reference for structure-activity relationship studies of NMDA receptor ligands.
    O-Phosphono-L-homoserine
  • HY-W721596
    Pentadecanoyl ethanolamide
    Pentadecanoyl ethanolamide is derivate of endougenous lipid amides, the N-acylethanolamines. Pentadecanoyl ethanolamide exhibits anticonvulsant efficacy in electroshocked mice without significant toxicity.
    Pentadecanoyl ethanolamide
  • HY-152940A
    αGlcCer
    αGlcCer is a glycosphingolipid, which was originally identified in marine sponges. αGlcCer is a lipid antigen for invariant natural killer T (iNKT) cells, and stimulates iNKT cells.
    αGlcCer
  • HY-Y1718R
    Tridecanoic acid (Standard)
    Tridecanoic acid (Standard) is the analytical standard of Tridecanoic acid. This product is intended for research and analytical applications. Tridecanoic acid (N-Tridecanoic acid), a 13-carbon medium-chain saturated fatty acid, can serve as an antipersister and antibiofilm agent that may be applied to research bacterial infections. Tridecanoic acid inhibits Escherichia coli persistence and biofilm formation.
    Tridecanoic acid (Standard)
  • HY-Y1366R
    Hydroxyacetone (Standard)
    Hydroxyacetone is a dehydration product of glycerol. Hydroxyacetone is a platform for the electrocatalytic synthesis of acetone, 1,2-propanediol and 2-propanol. Hydroxyacetone can also be used as a glycerol substitute for electrocatalytic hydrogenation and hydrodeoxygenation processes.
    Hydroxyacetone (Standard)
  • HY-D0837S
    Imidazole-d4
    		99.94%
    Imidazole-d4 is the deuterium labeled Imidazole.
    Imidazole-d<sub>4</sub>
  • HY-W010489S1
    2-Phenylacetaldehyde-13C2
    2-Phenylacetaldehyde-13C2 is 13C labeled 2-Phenylacetaldehyde (HY-W010489). 2-Phenylacetaldehyde is an endogenous metabolite.
    2-Phenylacetaldehyde-<sup>13</sup>C<sub>2</sub>
  • HY-W130074R
    α-Pinene oxide (Standard)
    α-Pinene oxide (Standard) is the analytical standard of α-Pinene oxide (HY-W130074). This product is intended for research and analytical applications. α-Pinene oxide is a type of monoterpene epoxidation intermediate. α-Pinene oxide is produced via the cytochrome P-450-mediated oxidation pathway in Dendroctonus terebrans body microsomes and rat liver microsomes, and can be further converted into alcohols, ketones and insect pheromone derivatives. α-Pinene oxide can generate the perfume intermediate myrtenal. α-Pinene oxide is used in studies related to terpenoid metabolism and perfume synthesis.
    α-Pinene oxide (Standard)
Cat. No. Product Name / Synonyms Application Reactivity
Endogenous Metabolite Isoform Comparison

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