2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endogenous Metabolite
  5. Endogenous Metabolite Agonist

Endogenous Metabolite Agonist

Endogenous Metabolite Isoform Comparison

Endogenous Metabolite Agonists (3):

Cat. No. Product Name Effect Purity
  • HY-175232
    GL64
    		Agonist 98.80%
    GL64 is a selective agonist of ADGRD1 (EC50 = 3.98 μM). GL64 has low selectivity for ADGRD2, ADGRG5, ADGRG6, CELSR1, CELSR2, CELSR3, and ADGRG4 isoforms. GL64 activates ADGRD1 by mimicking the satchel sequence. GL64 regulates osteoclast maturation through the cAMP-PKA-NFATC1 pathway. GL64 effectively inhibits osteoclastogenesis and prevents bone loss both in vitro and in vivo. GL64 is useful in the study of osteoclast-related diseases.
  • HY-115762
    4-Hydroxytryptamine creatinine sulfate
    		Agonist
    4-Hydroxytryptamine creatinine sulfate, a tryptamine derivative, is a neurotransmitter agonist.
  • HY-113724
    S-8666
    		Agonist
    S-8666 is an orally active uricosuric antihypertensive diuretic. The S-8666 has both S-(-)- and R-(+)-isomers. The diuretic and sodium-excretion activities of it are entirely dominated by the S-(-)-isomer, while the R-(+)-isomer shows no significant activity. S-8666 relies on the organic acid transport system to be secreted through the proximal tubule. S-8666 exhibits a clear uric acid excretion-promoting activity and diuretic effect in various species (such as rats and chimpanzees).