103968-87-2
Chemical Structure
S-8666
- CAS No.: 103968-87-2
- Formula:C11H11Cl2NO5S
- Molecular Weight:340.18
IUPAC Name: 6,7-dichloro-5-(N,N-dimethylsulfamoyl)-2,3-dihydrobenzofuran-2-carboxylic acid
InChIKey: ZTFUDCAAHOVUPH-UHFFFAOYSA-N
SMILES: O=C(C1OC2=C(C1)C=C(S(=O)(N(C)C)=O)C(Cl)=C2Cl)O
Biological Activity: S-8666 is an orally active uricosuric antihypertensive diuretic. The S-8666 has both S-(-)- and R-(+)-isomers. The diuretic and sodium-excretion activities of it are entirely dominated by the S-(-)-isomer, while the R-(+)-isomer shows no significant activity. S-8666 relies on the organic acid transport system to be secreted through the proximal tubule. S-8666 exhibits a clear uric acid excretion-promoting activity and diuretic effect in various species (such as rats and chimpanzees)[1][2].
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S-8666 | S-8666 is an orally active uricosuric antihypertensive diuretic. The S-8666 has both S-(-)- and R-(+)-isomers. The diuretic and sodium-excretion activities of it are entirely dominated by the S-(-)-isomer, while the R-(+)-isomer shows no significant activity. S-8666 relies on the organic acid transport system to be secreted through the proximal tubule. S-8666 exhibits a clear uric acid excretion-promoting activity and diuretic effect in various species (such as rats and chimpanzees). | |||||||||||||||||||||
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References
- [1]. Higaki K, Nakano M. Stereoselective disposition of S-8666, a novel uricosuric antihypertensive diuretic, and its N-monodemethylated metabolite in a perfused rat liver preparation. Effect of protein binding on the kinetics of S-8666. Drug Metab Dispos. 1992 May-Jun;20(3):350-5. [Content Brief]
- [2]. Yonetani Y, et al. A new uricosuric diuretic, S-8666, in rats and chimpanzees. Jpn J Pharmacol. 1987 Apr;43(4):389-98. doi: 10.1254/jjp.43.389. Yonetani Y, et al. A new uricosuric diuretic, S-8666, in rats and chimpanzees. Jpn J Pharmacol. 1987 Apr;43(4):389-98. doi: 10.1254/jjp.43.389. [Content Brief]
