S-8666
S-8666 is an orally active uricosuric antihypertensive diuretic. The S-8666 has both S-(-)- and R-(+)-isomers. The diuretic and sodium-excretion activities of it are entirely dominated by the S-(-)-isomer, while the R-(+)-isomer shows no significant activity. S-8666 relies on the organic acid transport system to be secreted through the proximal tubule. S-8666 exhibits a clear uric acid excretion-promoting activity and diuretic effect in various species (such as rats and chimpanzees).
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 103968-87-2
- Formel: C11H11Cl2NO5S
- Molecular Weight:340.18
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen
More
Biologische Aktivität
Chemical Information
-
CAS. Nr. 103968-87-2
-
Molecular Weight 340.18
-
Formel C11H11Cl2NO5S
-
SMILES
O=C(C1OC2=C(C1)C=C(S(=O)(N(C)C)=O)C(Cl)=C2Cl)O
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Higaki K, Nakano M. Stereoselective disposition of S-8666, a novel uricosuric antihypertensive diuretic, and its N-monodemethylated metabolite in a perfused rat liver preparation. Effect of protein binding on the kinetics of S-8666. Drug Metab Dispos. 1992 May-Jun;20(3):350-5. [Content Brief]
[2]. Yonetani Y, et al. A new uricosuric diuretic, S-8666, in rats and chimpanzees. Jpn J Pharmacol. 1987 Apr;43(4):389-98. doi: 10.1254/jjp.43.389. Yonetani Y, et al. A new uricosuric diuretic, S-8666, in rats and chimpanzees. Jpn J Pharmacol. 1987 Apr;43(4):389-98. doi: 10.1254/jjp.43.389. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
S-8666 Related Classifications
HY-113724 Related Classifications
Powered by Bioz