2. Signalwege
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Verwandte Produkte (2419):

Art. -Nr. Produktname Wirkung Reinheit Chemical Structure
  • HY-W586082
    N-Isobutyryl-2', 3'-acetyl-guanosine
    N-Isobutyryl-2',3'-Acetyl-Guanosine is a guanosine nucleoside derivative.
    N-Isobutyryl-2', 3'-acetyl-guanosine
  • HY-164247
    UnyLinker 12
    UnyLinker 12 is a universal linker that can be used for the synthesis of oligoribonucleotides.
    UnyLinker 12
  • HY-178680
    Im-GDP
    Im-GDP is a monomeric raw material that can be used for nucleic acid synthesis.
    Im-GDP
  • HY-W131753
    2'-F-Ac-C
    		99.64%
    2'-F-Ac-C (N-Acetyl-2′-deoxy-2′-fluorocytidine) is a nucleoside analog that can be used to synthesize oligoribonucleotides.
    2'-F-Ac-C
  • HY-177787A
    2'-Deoxy-N-methyl-AMP ammonium
    2'-Deoxy-N-methyl-AMP ammonium is an N6-substituted adenine nucleotide derivative and a glycosyl donor. On one hand, 2'-Deoxy-N-methyl-AMP ammonium acts as a specific substrate for N6-methyl-AMP aminohydrolase, and it is catalytically converted to dIMP to participate in the nucleotide metabolic cycle. On the other hand, 2'-Deoxy-N-methyl-AMP ammonium also serves as a guanosine diphosphate (GDP)-linked fucose derivative donor, driving site-specific glycoconjugation of proteins under the mediation of α-1,3-fucosyltransferase. 2'-Deoxy-N-methyl-AMP ammonium is an important molecular tool for investigating the mechanisms of nucleotide modification and protein glycosylation.
    2'-Deoxy-N-methyl-AMP ammonium
  • HY-45281
    N6-Benzoyl-5'-O-DMT-3'-O-methyladenosine 3'CE-phosphoramidite
    		98.04%
    N6-Benzoyl-5'-O-DMT-3'-O-methyladenosine 3'CE-phosphoramidite is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
    N6-Benzoyl-5'-O-DMT-3'-O-methyladenosine 3'CE-phosphoramidite
  • HY-134337
    5'-O-DMTr-3'-O-methyl uridine-3'-CED-phosphoramidite
    		98.01%
    5'-O-DMTr-3'-O-methyl uridine-3'-CED-phosphoramidite is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents.
    5'-O-DMTr-3'-O-methyl uridine-3'-CED-phosphoramidite
  • HY-W011526
    2-Amino-2'-fluoro-2'-deoxyadenosine
    		98.80%
    2-Amino-2'-fluoro-2'-deoxyadenosine is a building block of nucleic acid.
    2-Amino-2'-fluoro-2'-deoxyadenosine
  • HY-159806
    UU
    		99.81%
    UU ((3′,5′)-Uridylyluridine) is a nucleobase-containing dinucleotide derivative. UU can be used for the study of RNA-related processes.
    UU
  • HY-W1119956
    5’-(E)-VPG Phosphoramidite
    		99.42%
    5'-(E)-VPG Phosphoramidite (5'(E)-VP-2'-OMe-iBu-GPhosphoramidite) is a structurally modified phosphoramidite reagent used to synthesize biologically stable oligonucleotides. 5'-(E)-VPG Phosphoramidite (POM) carries a VP protecting group and can be coupled to the target oligonucleotide at the 5' end via solid-phase synthesis. The modified oligonucleotide is then constructed through oxidation and deprotection steps. 5'-(E)-VPG Phosphoramidite is suitable for RNAi and viral replication research.
    5’-(E)-VPG Phosphoramidite
  • HY-178589
    Biotin-7-GMP
    Biotin-7-GMP (5'-Biotin-G-monophosphate) is a monomeric raw material that can be used for nucleic acid synthesis.
    Biotin-7-GMP
  • HY-W091754
    5'-O-Dmt-n2-isobutyryl-2'-o-methyl-d-guanosine
    		98.66%
    5'-O-Dmt-n2-isobutyryl-2'-o-methyl-d-guanosine is a nucleoside that is made using an oxime opening of the 5' position and a methylation at the 2' position. 5'-O-Dmt-n2-isobutyryl-2'-o-methyl-d-guanosine has been shown to have an affinity for tissues in a chemotactic assay.
    5'-O-Dmt-n2-isobutyryl-2'-o-methyl-d-guanosine
  • HY-150773S1
    Guanosine triphosphate-d14 dilithium
    Guanosine triphosphate-d14 (GTP-d14) dilithium is a deuterium labeled Guanosine triphosphate (HY-113225). Guanosine triphosphate is a native nucleotide. The derivatives of GTP may be used as specific inhibitors against COVID-19.
    Guanosine triphosphate-d<sub>14</sub> dilithium
  • HY-B0158S5
    Cytidine-13C9,15N3
    		98.9%
    Cytidine-13C9,15N3 is the 13C and 15N labeled Cytidine. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function.
    Cytidine-<sup>13</sup>C<sub>9</sub>,<sup>15</sup>N<sub>3</sub>
  • HY-152682
    5-Ethyluridine
    		99.81%
    5-Ethyluridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5-Ethyluridine
  • HY-159806A
    UU TEA
    UU ((3′,5′)-Uridylyluridine) TFA is a nucleobase-containing dinucleotide derivative. UU TFA can be used for the study of RNA-related processes.
    UU TEA
  • HY-125818S1
    Cytidine-5′-triphosphate-d14 disodium
    		98.00%
    Cytidine-5′-triphosphate-d14 disodium is the deuterium labeled Cytidine-5'-triphosphate. Cytidine 5′-triphosphate (Cytidine triphosphate;5'-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule in the de novo pyrimidine biosynthetic pathway in T. gondii.
    Cytidine-5′-triphosphate-d<sub>14</sub> disodium
  • HY-177165
    3'-NH2-CTP
    3'-NH2-CTP is a nucleotide analog with an amino group modified at the 3' end of CTP.
    3'-NH2-CTP
  • HY-148169
    2'-Deoxy-L-guanosine
    		99.30%
    2'-Deoxy-L-guanosine selectively inhibits D-Thymidine phosphorylation catalyzed by HSV 1 thymidine kinase. 2'-Deoxy-L-guanosine is the L-configuration of 2'-Deoxyguanosine (HY-17563).
    2'-Deoxy-L-guanosine
  • HY-154658
    2’-Deoxy-2’-fluoro-N3-[(pyrid-4-yl)methyl]-beta-D-arabinouridine
    2’-Deoxy-2’-fluoro-N3-[(pyrid-4-yl)methyl]-beta-D-arabinouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2’-Deoxy-2’-fluoro-N3-[(pyrid-4-yl)methyl]-beta-D-arabinouridine