1. Cell Cycle/DNA Damage
  2. Nucleoside Antimetabolite/Analog
  3. 2-Amino-2'-fluoro-2'-deoxyadenosine

2-Amino-2'-fluoro-2'-deoxyadenosine is a building block of nucleic acid.

For research use only. We do not sell to patients.

2-Amino-2'-fluoro-2'-deoxyadenosine

2-Amino-2'-fluoro-2'-deoxyadenosine Chemical Structure

CAS No. : 134444-47-6

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  • Biological Activity

  • Purity & Documentation

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Description

2-Amino-2'-fluoro-2'-deoxyadenosine is a building block of nucleic acid[1].

Cellular Effect
Cell Line Type Value Description References
HepG2 EC50
>10 μM
Compound: 22
compound was tested in vitro for anti HBV activity in HepG2 2.2.15 cells
compound was tested in vitro for anti HBV activity in HepG2 2.2.15 cells
[PMID: 9276020]
HepG2 IC50
>180 μM
Compound: 22
The cytotoxicity against 2.2.15 cells expressed as IC50
The cytotoxicity against 2.2.15 cells expressed as IC50
[PMID: 9276020]
Molecular Weight

284.25

Formula

C10H13FN6O3

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@@H](F)[C@H](N2C3=NC(N)=NC(N)=C3N=C2)O[C@@H]1CO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 8.33 mg/mL (29.31 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5180 mL 17.5902 mL 35.1803 mL
5 mM 0.7036 mL 3.5180 mL 7.0361 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5180 mL 17.5901 mL 35.1803 mL 87.9507 mL
5 mM 0.7036 mL 3.5180 mL 7.0361 mL 17.5901 mL
10 mM 0.3518 mL 1.7590 mL 3.5180 mL 8.7951 mL
15 mM 0.2345 mL 1.1727 mL 2.3454 mL 5.8634 mL
20 mM 0.1759 mL 0.8795 mL 1.7590 mL 4.3975 mL
25 mM 0.1407 mL 0.7036 mL 1.4072 mL 3.5180 mL
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2-Amino-2'-fluoro-2'-deoxyadenosine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
2-Amino-2'-fluoro-2'-deoxyadenosine
Cat. No.:
HY-W011526
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