2'-Deoxy-N-methyl-AMP ammonium 

2'-Deoxy-N-methyl-AMP ammonium is an N6-substituted adenine nucleotide derivative and a glycosyl donor. On one hand, 2'-Deoxy-N-methyl-AMP ammonium acts as a specific substrate for N6-methyl-AMP aminohydrolase, and it is catalytically converted to dIMP to participate in the nucleotide metabolic cycle. On the other hand, 2'-Deoxy-N-methyl-AMP ammonium also serves as a guanosine diphosphate (GDP)-linked fucose derivative donor, driving site-specific glycoconjugation of proteins under the mediation of α-1,3-fucosyltransferase. 2'-Deoxy-N-methyl-AMP ammonium is an important molecular tool for investigating the mechanisms of nucleotide modification and protein glycosylation^[1][2].

2'-Deoxy-N-methyl-AMP ammonium (Optimized time intervals for conversion; 37 °C) is efficiently converted to dIMP by purified rat liver N⁶-methyl-AMP aminohydrolase, with a K_m of 0.9 ± 0.2 μmol/L, V_max of 253.7 ± 10.1 nmol min^-1 mg^-1, and V_max/K_m ratio of 281.9 × 10³ L min^-1 mg^-1[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

362.28

C₁₁H₁₉N₆O₆P

Solid

O[C@H]1C[C@H](N(C=N2)C3=C2C(NC)=NC=N3)O[C@@H]1COP(O)(O)=O.N

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Schinkmanová M, et al. N6-methyl-AMP aminohydrolase activates N6-substituted purine acyclic nucleoside phosphonates. Biochem Pharmacol. 2006;71(9):1370-1376.  [Content Brief]

  [2]. SITE-SPECIFIC GLYCOPROTEIN CONJUGATES AND METHODS FOR MAKING THE SAME. WIPO Patent Application. WO2023065137.