Amino Acid Derivatives

Amino Acid Derivatives are bioactive molecules formed through chemical modifications or metabolic transformations of amino acids. They are widely present in living organisms and play crucial roles in physiological, psychological, and athletic performance.
The functions of these derivatives primarily include enhancing energy supply, regulating neurotransmitters, promoting fat metabolism, and reducing muscle damage. For example, creatine can increase muscle strength, enhance ATP resynthesis, and improve short-duration high-intensity exercise performance; tyrosine, as a precursor of dopamine and norepinephrine, helps enhance cognitive function and improve mood, particularly in sleep deprivation conditions, exhibiting anti-fatigue effects; carnitine facilitates fatty acid oxidation in the heart and skeletal muscles, improving endurance performance; HMB (β-hydroxy-β-methylbutyrate) reduces muscle breakdown and promotes muscle mass gain; while taurine exhibits antioxidant and antihypertensive properties and reduces oxidative stress induced by exercise.
Metabolic abnormalities or improper supplementation of amino acid derivatives may be associated with various diseases. For instance, tyrosine metabolism disorders can disrupt neurotransmitter balance, potentially leading to depression or stress-related disorders; elevated ADMA (asymmetric dimethylarginine) levels can inhibit nitric oxide synthesis, increasing the risk of cardiovascular diseases; carnitine deficiency is linked to certain genetic muscle disorders, impairing fat metabolism and energy production. Additionally, HMB may help slow muscle loss under specific conditions, while taurine intake is associated with improved cardiovascular health. Although some of the effects of these derivatives remain debated, they hold significant potential applications in sports nutrition, neurological regulation, and metabolic health.

References:

[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-807. [Content Brief]

Amino Acid Derivatives Related Products (1734):

By Effects:	Inhibitor (1) Chemical (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-W008696

Fmoc-Thr-OH		99.37%
Fmoc-Thr-OH is a threonine derivative.

HY-W007942

Fmoc-β-Ala-OH		99.93%
Fmoc-β-Ala-OH is an alanine derivative.

HY-W011830

H-Phe-OtBu.HCl		99.44%
H-Phe-OtBu.HCl is a phenylalanine derivative.

HY-20897A

5-Bromo-L-tryptophan		99.78%
5-Bromo-L-tryptophan is an α-amino acid derivative that can be found in Semenospongia sp.. 5-Bromo-L-tryptophan can be used to synthesize 5-bromoindole (HY-30236).

HY-W008075

Fmoc-Asp(OAll)-OH		99.89%
Fmoc-Asp(OAll)-OH is an aspartic acid derivative.

HY-W259767

3-Iodo-L-phenylalanine		99.69%
3-Iodo-L-phenylalanine is an unnatural amino acid that can be used for partial codon redistribution. 3-Iodo-L-phenylalanine has a high efficiency in Ser AGU codon reassignment, and also has a certain effect in Ser UCG codon reassignment. 3-Iodo-L-phenylalanine can be used in the study of genetic code expansion and protein engineering.

HY-W010156

O-(tert-Butyl)-L-serine		99.70%
O-(tert-Butyl)-L-serine is a serine derivative.

HY-A0282

L-Ornithine L-aspartate		98.0%
L-Ornithine L-aspartate is a stable salt of two natural nonessential L-amino acids with oral activity: ornithine and aspartic acid. L-Ornithine L-aspartate lowers blood ammonia concentration and to eliminate symptoms of hepatic encephalopathy associated with liver cirrhosis. L-Ornithine L-aspartate also improves mitochondrial functions.

HY-W018004

L-Homocitrulline		99.53%
L-Homocitrulline is a carbamoylated derivative amino acid and a structural analog of L-citrulline. L-Homocitrulline serves not only as an intermediate in polypeptide synthesis but also converts into a variety of cyclic derivatives under enzymatic or acidic conditions. The level of L-Homocitrulline is significantly elevated in the serum of patients with non-alcoholic fatty liver disease (NAFLD), with high diagnostic accuracy. L-Homocitrulline also exists in patients with related diseases such as hypercitrullinemia. L-Homocitrulline is a key biomarker for monitoring abnormal liver metabolism and is widely used in NAFLD research.

HY-W013962

4-(Trifluoromethyl)-L-phenylalanine		99.89%
4-(Trifluoromethyl)-L-phenylalanine is a phenylalanine derivative.

HY-W000795

(S)-2-amino-3-(4-benzoylphenyl)propanoic acid		99.77%
(S)-2-amino-3-(4-benzoylphenyl)propanoic acid is an alanine derivative.

HY-113286

4-Guanidinobutanoic acid		98.0%
4-Guanidinobutanoic acid is a common urinary metabolite and arginine metabolite. 4-Guanidinobutanoic acid can be used in the research of fibromyalgia.

HY-P10493

NY-ESO-1 (157-165) peptide		99.75%
NY-ESO-1 (157-165) peptide is a peptide fragment from NY-ESO-1 protein. NY-ESO-1 (157-165) peptide can activate the immune system, especially for HLA-A2 positive individuals, it can be recognized by CD8+ T cells, thus triggering an immune response. NY-ESO-1 (157-165) peptide is expressed in a variety of tumors and can be used as a target for tumor immunotherapy.

HY-114348

N,N'-Diacetyl-L-cystine		99.06%
N,N'-diacetyl-L-cystine (DiNAC) is the disulphide dimer of N-acetylcysteine with immunomodulating properties. N,N'-diacetyl-L-cystine is a potent, orally active modulator of contact sensitivity/delayed type hypersensitivity reactions in rodents. N,N'-diacetyl-L-cystine also has antiatherosclerotic effects in Watanabe-heritable hyperlipidemic rabbit (WHHL) rabbits.

HY-W048217

N6-Butyryl-L-lysine		99.98%
N6-Butyryl-L-lysine is a lysine derivative.

HY-137875

Hippuryl-His-Leu-OH hydrate		99.88%
Hippuryl-His-Leu-OH (N-Benzoyl-Gly-His-Leu) hydrate is a specific substrate for angiotensin-converting enzyme ACE I and is a molecular tool used for ACE activity detection in in vitro experiments. Hippuryl-His-Leu-OH hydrate is hydrolyzed by ACE through competitive binding. Under ACE catalysis, Hippuryl-His-Leu-OH hydrate undergoes hydrolysis to produce hippuric acid (HA). The amount of HA produced can be used to quantitatively assess ACE activity or screen for ACE inhibitors. The His-Leu released from Hippuryl-His-Leu-OH hydrate can also react with o-phthalaldehyde or Fluorescamine (HY-D0715) for fluorescence detection. Hippuryl-His-Leu-OH hydrate can be applied to the in vitro screening of ACE inhibitors for hypertension and cardiovascular diseases, and is also used in the study of changes in ACE activity during physiological and pathological processes such as renal compensatory hypertrophy.

HY-Z0424

(S)-2-[(tert-Butoxycarbonyl)amino]-3-iodopropionic acid methyl ester		99.20%
(S)-2-[(tert-Butoxycarbonyl)amino]-3-iodopropionic acid methyl ester is an alanine derivative.

HY-W009592

Glycyl-L-tyrosine		99.59%
Glycyl-L-tyrosine is a synthetic dipeptide that can be used as a food additive for tyrosine supplementation.

HY-W010959

Fmoc-Asp-OtBu		99.97%
Fmoc-Asp-OtBu is an aspartic acid derivative.

HY-W011342

Fmoc-Sar-OH		99.93%
Fmoc-Sar-OH is a Glycine (HY-Y0966) derivative.

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