Amino Acid Derivatives

Amino Acid Derivatives are bioactive molecules formed through chemical modifications or metabolic transformations of amino acids. They are widely present in living organisms and play crucial roles in physiological, psychological, and athletic performance.
The functions of these derivatives primarily include enhancing energy supply, regulating neurotransmitters, promoting fat metabolism, and reducing muscle damage. For example, creatine can increase muscle strength, enhance ATP resynthesis, and improve short-duration high-intensity exercise performance; tyrosine, as a precursor of dopamine and norepinephrine, helps enhance cognitive function and improve mood, particularly in sleep deprivation conditions, exhibiting anti-fatigue effects; carnitine facilitates fatty acid oxidation in the heart and skeletal muscles, improving endurance performance; HMB (β-hydroxy-β-methylbutyrate) reduces muscle breakdown and promotes muscle mass gain; while taurine exhibits antioxidant and antihypertensive properties and reduces oxidative stress induced by exercise.
Metabolic abnormalities or improper supplementation of amino acid derivatives may be associated with various diseases. For instance, tyrosine metabolism disorders can disrupt neurotransmitter balance, potentially leading to depression or stress-related disorders; elevated ADMA (asymmetric dimethylarginine) levels can inhibit nitric oxide synthesis, increasing the risk of cardiovascular diseases; carnitine deficiency is linked to certain genetic muscle disorders, impairing fat metabolism and energy production. Additionally, HMB may help slow muscle loss under specific conditions, while taurine intake is associated with improved cardiovascular health. Although some of the effects of these derivatives remain debated, they hold significant potential applications in sports nutrition, neurological regulation, and metabolic health.

References:

[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-807. [Content Brief]

Amino Acid Derivatives Related Products (1734):

By Effects:	Inhibitor (1) Chemical (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-Y0168

L-(-)-Phenylalaninol		99.11%
L-(-)-Phenylalaninol is an alanine derivative.

HY-W007578

H-β-Ala-OtBu.HCl		98.13%
H-β-Ala-OtBu.HCl is an alanine derivative.

HY-W008079

(S)-2-Amino-6-((tert-butoxycarbonyl)amino)hexanoic acid		99.68%
(S)-2-Amino-6-((tert-butoxycarbonyl)amino)hexanoic acid is a lysine derivative.

HY-W011056

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(furan-2-yl)propanoic acid		99.66%
(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(furan-2-yl)propanoic acid is an alanine derivative.

HY-W009151

Fmoc-Abu-OH		99.80%
Fmoc-Abu-OH is an alanine derivative.

HY-W141928

N-Isobutyrylglycine
N-Isobutyrylglycine is a Glycine (HY-Y0966) derivative.

HY-W013292

(S)-2-((tert-Butoxycarbonyl)amino)-3-(4-hydroxyphenyl)propanoic acid		99.99%
(S)-2-((tert-Butoxycarbonyl)amino)-3-(4-hydroxyphenyl)propanoic acid is a tyrosine derivative.

HY-W013163

(R)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-phenylpropanoic acid		99.74%
(R)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-phenylpropanoic acid is a phenylalanine derivative.

HY-W008642

Leu-Leu-OH		99.10%
Leu-Leu-OH (L-Leucyl-L-leucine), a Leu derivative, is a neutral dipeptide that can be used to study the functionality of dileucine motifs.

HY-W587803

Propionylglycine		98.0%
Propionylglycine is a peptide.

HY-W015230

Boc-Sar-OH		98.0%
Boc-Sar-OH is a Glycine (HY-Y0966) derivative.

HY-W013726

Fmoc-Phe(4-Br)-OH		99.83%
Fmoc-Phe(4-Br)-OH is a widely used amino acid derivative. Fmoc-Phe(4-Br)-OH can be used in the synthesis of compounds and for the study of protein-protein interactions and the development of biomaterials. Fmoc-Phe(4-Br)-OH can be used in peptide synthesis to incorporate phenylalanine bromide into the peptide chain.

HY-W008178

(R)-2-((tert-Butoxycarbonyl)amino)-3-(tritylthio)propanoic acid		99.87%
(R)-2-((tert-Butoxycarbonyl)amino)-3-(tritylthio)propanoic acid is a cysteine derivative.

HY-119543

O-Succinyl-L-homoserine		98.0%
O-Succinyl-L-homoserine is a homoserine derivative. O-Succinyl-L-homoserine is an intermediate in the biosynthesis of methionine in Escherichia coli and Salmonella typhimurium.

HY-79877

Boc-Ser(Tos)-OMe		≥99.0%
Boc-Ser(Tos)-OMe is a serine derivative.

HY-W010162

H-Ala-Ala-OH		98.0%
H-Ala-Ala-OH is a substrate of human intestinal oligopeptide transporter (PEPT1/SLC15A1), with an IC₅₀ of 0.25 mM and an EC₅₀ of 0.08 mM against human PEPT1. When used as a dipeptide linker in antibody-drug conjugates (ADCs) loaded with glucocorticoid receptor regulator payloads, H-Ala-Ala-OH enables efficient intracellular payload release.

HY-42709

Z-Val-Ala-OH		99.78%
Z-Val-Ala-OH is a dipeptide derivative of valine and alanine. Z-Val-Ala-OH undergoes cleavage by cathepsin B and other lysosomal proteases to enable payload release following lysosomal internalization. Z-Val-Ala-OH can be used for the research of antibody-drug conjugate (ADC) development[1].

HY-40114

Boc-L-proline		99.79%
Boc-L-proline is an amino acid derivative. As an important intermediate in organic synthesis, Boc-L-proline can be used for peptide synthesis.

HY-W002074

D-Cysteine hydrochloride		98.0%
D-Cysteine hydrochloride is a cysteine derivative.

HY-W009118

Fmoc-5-Ava-OH		99.49%
Fmoc-5-Ava-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize fatty acid-based dimeric peptides with PSD-95 inhibitory activity.

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