Drug Isomer
Drug Isomer
Drug isomers are compounds with the same molecular formula but different atomic arrangements or spatial configurations. They are divided into structural isomers and stereoisomers, and have different biological activities, safety and metabolic characteristics. Drug isomers can be used as drug improvement groups or drug efficacy control groups. For example, Carvedilol has higher bioavailability and better safety than (R)-Carvedilol.
References:
- [1]. Evans AM, et al. Comparative pharmacology of S(+)-ibuprofen and (RS)-ibuprofen. Clin Rheumatol. 2001 Nov;20 Suppl 1:S9-14. [Content Brief]
- [2]. Andersson T. Single-isomer drugs: true therapeutic advances. Clin Pharmacokinet. 2004;43(5):279-85. [Content Brief]
- [3]. Chhabra N, et al. A review of drug isomerism and its significance. Int J Appl Basic Med Res. 2013 Jan;3(1):16-8. [Content Brief]
All Product Categories
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Drug Isomer Related Products (557)
Related Products (557)
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ent-DMPC
0 ImagesCat. No.: HY-N15910CAS No.: 64234-00-0ent-DMPC is an enantiomer of Colfosceril miristate (DMPC) (HY-109541).
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(E)-IDO1/TDO-IN-5
0 ImagesCat. No.: HY-148336CAS No.: 2407753-09-5(E)-IDO1/TDO-IN-5 is the E configuration of IDO1/TDO-IN-5 (HY-148336A). IDO1/TDO-IN-5 is a dual IDO1/TDO inhibitor with IC50 values of 0.018 and 0.025 μM, respectively.
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Isoquinoline (Standard)
0 ImagesIsoquinoline (Standard) is the analytical standard of Isoquinoline. This product is intended for research and analytical applications. Isoquinoline is an analog of pyridine. Isoquinoline structural-based alkaloids, such as tropoloisoquinoline, phthalideisoquinoline, and naphthylisoquinoline has anti-cancer activities.
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Cascaroside F
0 ImagesCat. No.: HY-N21607CAS No.: 164322-83-2Cascaroside F is an O,C-diglucosyl anthrone natural product found in the bark of Rhamnus purshiana, belonging to the emodin series of 10-C-β-D-glucopyranosyl-9-anthrones.
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Conjugated linoleic acid
0 ImagesCat. No.: HY-167917CAS No.: 121250-47-3Conjugated linoleic acid is a group of isomers of Linoleic acid (HY-N0729) containing conjugated double bonds. Conjugated linoleic acid is mainly derived from dairy products and ruminant meats. Conjugated linoleic acid exhibits various activities such as anti-carcinogenicity, immunomodulation, weight loss promotion, reduction of muscle damage, and alleviation of inflammatory responses. Conjugated linoleic acid can be used as a food additive.
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IMP-2958
0 ImagesCat. No.: HY-184153CAS No.: 3129691-65-9IMP-2958 is an inactive enantiomeric negative control probe with significantly reduced binding to RAB27A/B-Cys123.IMP-2958 serves as a negative control probe for off-target binding in phenotypic assays related to RAB27A/B studies.IMP-2958 functions as a control for stereoselective targeted covalent inhibitors of the RAB27-effector protein-protein interaction.
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(S)-Imlunestrant tosylate
0 ImagesSynonyms: (S)-LY-3484356 tosylate(S)-Imlunestrant ((S)-LY-3484356) tosylate is an (S)-enantiomer of Imlunestrant (HY-145572). (S)-Imlunestrant tosylate can be used in research of cancer.
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(R)-Taltobulin
0 ImagesCat. No.: HY-15584CCAS No.: 228266-44-2Synonyms: (R)-HTI-286; (R)-SPA-110(R)-Taltobulin ((R)-HTI-286) can be used as a reference substance.
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(rac)-AG-205
0 ImagesCat. No.: HY-121012CAS No.: 442656-02-2(rac)-AG-205 is an isomer of AG-205 (HY-115625). AG-205 is an antagonist of progesterone receptor membrane component 1 (PGRMC1) and an inhibitor of ceramide galactosyltransferase (CGT); it can be used in research related to renal cancer and breast cancer..
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(Rac)-EBET-590
0 ImagesCat. No.: HY-161387ACAS No.: 3031540-02-7(Rac)-EBET-590 is the racemate of EBET-590 (HY-161387). (Rac)-EBET-590 is a BET ligand. (Rac)-EBET-590 can serve as a ligand for the target protein in the synthesis of PROTAC BET degraders, such as (Rac)-EBET-1055 (HY-161346A). (Rac)-EBET-590 is suitable for cancer research.
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(S)-Sitagliptin phosphate
0 ImagesCat. No.: HY-13749CCAS No.: 823817-58-9Synonyms: (S)-MK-0431 phosphate(S)-Sitagliptin phosphate ((S)-MK-0431 phosphate) is the S-isomer of Sitagliptin phosphate (HY-13749A). Sitagliptin phosphate (MK-0431 phosphate) is a potent DPP4 inhibitor. (S)-Sitagliptin phosphate can be used in diabetes research.
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Z-CITCO
0 ImagesCat. No.: HY-155295CAS No.: 2583138-04-7Z-CITCO is the cis isomer of CITCO (HY-103244). Z-CITCO is an agonist of constitutive androstane receptor (CAR) with an EC50 value of 3.9 µM.
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α-Nicotine
0 ImagesCat. No.: HY-W698445CAS No.: 23950-04-1α-Nicotine is the α-isomer of Nicotine. Nicotine is a nicotinic acetylcholine receptor (nAChR) agonist. Nicotine is promising for research of neuropsychiatric disorders (e.g., schizophrenia, ADHD).
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(R)-Camptothecin
0 ImagesCat. No.: HY-16560BCAS No.: 110351-92-3Synonyms: (R)-Campathecin; (R)-(+)-Camptothecin; (R)-CPT(R)-Camptothecin is an enantiomer of Camptothecin (CPT), is inactive as an inhibitor of the DNA religation reaction and consequently do not poison Top1.
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Teprenone Impurity 5
0 ImagesTeprenone Impurity 5 (5Z-GGA) is the cis-isomer of Teprenone (HY-B0779). Teprenone Impurity 5 has inhibitory activity on the proliferation of human ovarian cancer cells Caov-3, and can block the invasion process of cancer cells. Teprenone Impurity 5 can induce the expression of heat shock protein 70 (HSP70) and thioredoxin (Trx). Teprenone Impurity 5 can be used for the research of ovarian cancer.
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cis-V-11-0711
0 ImagesCat. No.: HY-120337BCAS No.: 1428338-79-7cis-V-11-0711 is the cis form of V-11-0711 (HY-120337). V-11-0711 is a potent and selective Chk-α (IC50 = 20 nM) inhibitor. V-11-0711 can significantly reduce PCho levels. V-11-0711 causes a reversible growth arrest. V-11-0711 induces apoptosis at high concentrations. V-11-0711 can be used for the study of cervical cancer and triple-negative breast cancer.
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(R)-LY-41
0 ImagesCat. No.: HY-165624BCAS No.: 136296-43-0(R)-LY-41, R-enantiomer of LY-41 (HY-165624), is 2-Sminotetralin (HY-W022362) derivative and 8-OH-DPAT (HY-112061) analogue. (R)-LY-41 is a potent and selective 5-HT1A receptor agonist. (R)-LY-41 can reduce the accumulation of 5-hydroxytryptophan (the precursor for 5-HT synthesis) in the rat brain induced by decarboxylase inhibitors (NSD 1015). (R)-LY-41 can lower the body temperature of rats and inhibit the escape response from the cage. (R)-LY-41 can induce the 5-HT behavioral syndrome but is weaker than (S)-LY-41 (HY-165624A). (R)-LY-41 can be used for the research of neurological disease, such as depression and anxiety.
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(3R,5R)-Rosuvastatin Lactone
0 ImagesCat. No.: HY-135406CAS No.: 1422954-11-7(3R,5R)-Rosuvastatin Lactone is an isomer of Rosuvastatin Lactone.
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CCT373567
0 ImagesCat. No.: HY-146184CAS No.: 2378853-67-7CCT373567 is a non-degrading isomer of the BCL6 degrader CCT373566 (HY-146185). CCT373567 acts as a BCL6 inhibitor with an IC50 of 2.9 nM. CCT373567 exerts growth inhibitory activity against cancer cells expressing BCL6, but shows low activity against cancer cells with low BCL6 expression. CCT373567 can be used in research related to diffuse large B-cell lymphoma.
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(E)-1α,25-Dihydroxyprevitamin D3
0 ImagesCat. No.: HY-131450ACAS No.: 96862-25-8(E)-1α,25-Dihydroxyprevitamin D3 is a structurally related analog of 1α,25(OH)2D3.
