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  4. Fluorescent Dye

Fluorescent Dye

Fluorescence is a phenomenon of photoluminescence in luminescence. When an atom is irradiated by light, some electrons around the nucleus jump from their original orbitals to higher energy orbitals under the influence of light energy, i.e., from the ground state to the first or second excited single-line state, etc. Due to the instability of the first or second excited singlet state, the electron returns from the excited singlet state to the ground state accompanied by released energy, resulting in fluorescence.

Fluorescent dyes can be covalently bound or physically adsorbed in the structure of the substance. The fluorescence properties allow for the characterization, localization and quantitative analysis of the labeled object. Fluorescent dyes have shown great potential for the detection of proteins, nucleic acids, cells, and immunoassays, attributed to the advantages in non-radioactive contamination, simple experimental operation and easy observation.

Fluorescent dyes have penetrated many fields such as pharmacology, physiology, environmental science, and information science, as well as functional studies of proteins and drug screening.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-D2895
    RB-PEG400-NH2
    RB-PEG400-NH2 (Rhodamine B-PEG400-NH2) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and an amino group. The reactive primary amine or NH2 groups can react rapidly with activated carboxylic acids such as NHS esters to form stable amide bonds (Ex/Em=546/610 nm).
    RB-PEG400-NH2
  • HY-D1375A
    Sulfo-Cy5 amine hydrochloride
    Sulfo-Cy5 amine hydrochloride is a near-infrared (NIR) amino fluorescent dye. Sulfo-Cy5 amine hydrochloride reacts with electrophilic substances.
    Sulfo-Cy5 amine hydrochloride
  • HY-P3364
    Ac-QPKK(Ac)-AMC
    Ac-QPKK(Ac)-AMC is a p53-derived peptide conjugated with a fluorophore, which serves as a fluorescent peptide substrate for detecting the deacylase activity of zinc-dependent HDACs and sirtuins (Ex = 360 nm; Em = 460 nm).
    Ac-QPKK(Ac)-AMC
  • HY-D2049
    ATTO 532 biotin
    ATTO 532 biotin is a biotin derivative of ATTO 532 with maximum excitation/emission wavelengths: 532/552 nm.
    ATTO 532 biotin
  • HY-W783351
    CS790AM
    CS790AM (Coppersensor 790 acetoxymethyl ester) is a cell-permeable, Cu+-targeted near-infrared fluorescent probe (λabs=760 nm, λem=790 nm) applicable to live cells. CS790AM can cross lipophilic cell membranes, and is converted into negatively charged CS790 under the action of intracellular esterases to be retained, thus enabling highly sensitive, reversible "turn-on" detection of labile Cu+ pools in live cells and mice. CS790AM possesses excellent biocompatibility and selectivity, avoids interference from other metal ions, shows no obvious toxicity, and can be rapidly cleared. CS790AM allows long-term longitudinal monitoring of individual mice, visualizes copper levels in internal organs and isolated livers, and effectively evaluates abnormal copper accumulation in Wilson's disease models (Atp7b-/-) as well as dynamic changes after chelator treatment. CS790AM can be used for research on Wilson's disease and related copper metabolic disorders.
    CS790AM
  • HY-D3264
    SiR-PEG4-DBCO
    SiR-PEG4-DBCO is a novel fluorescent labeling molecule that combines the superior fluorescent properties of silicon-rhodamine dyes with the functionalities of polyethylene glycol (PEG) and Click Chemistry. SiR dyes exhibit excellent photostability under identical excitation conditions, making them suitable for long-term cellular imaging (Ex = 640 nm, Em = 670-680 nm).
    SiR-PEG4-DBCO
  • HY-150364C
    FAM labled Farabursen sodium
    FAM labled Farabursen sodiumis a FAM labled Farabursen sodium.
    FAM labled Farabursen sodium
  • HY-D2940
    SiR-SNAP
    SiR-SNAP (SiR650-BG) is a SiR-labeled SNAP tag near-infrared fluorescent probe (Ex/Em: 645 nm/661 nm). SiR-SNAP combines excellent optical properties, good cell membrane permeability, and environmentally sensitive fluorescence characteristics, providing a powerful tool for the dynamic study of proteins in living cells.
    SiR-SNAP
  • HY-179074A
    FITC-Polysucrose 40
    FITC-Polysucrose 40 is FITC-labeled Polysucrose 40 (HY-131960C). Polysucrose 40 is a copolymer of sucrose and epichlorohydrin. Polysucrose 40 can be used to prepare cross-linked polysucrose microspheres. FITC-Polysucrose 40 is mainly used for permeability and microcirculation studies (Ex/Em = 488/525 nm).
    FITC-Polysucrose 40
  • HY-D2963
    R-MA-SLM
    R-MA-SLM is an Aβ-targeted and blood-brain barrier-permeable ratiometric H2O2-responsive fluorescent probe. When excited at 490 nm, the fluorescence intensity of the R-MA-SLM gradually decreases at 574 nm, while the emission intensity gradually increases at 661 nm. R-MA-SLM can detect and exhibits a ratiometric response to Aβ-induced endogenous H2O2. R-MA-SLM can be used in the research of Alzheimer's disease.
    R-MA-SLM
  • HY-132585D
    FAM labled Vesleteplirsen sodium
    FAM labled Vesleteplirsen sodiumis a FAM labled Vesleteplirsen sodium.
    FAM labled Vesleteplirsen sodium
  • HY-D3048C
    Rhodamine B-Chitosan (MW 20000)
    Rhodamine B-Chitosan (MW 20000) is a Rhodamine B (HY-Y0016)-labeled chitosan with a molecular weight of 20,000. Rhodamine B-Chitosan (MW 20000) combines the polysaccharide properties of chitosan with the fluorescence properties of Rhodamine B, playing an important role in fields such as fluorescent labeling, cell imaging, and drug delivery research (Ex/Em = 546/610 nm).
    Rhodamine B-Chitosan (MW 20000)
  • HY-148827D
    FAM labled GEM-231 sodium
    FAM labled GEM-231 sodiumis a FAM labled GEM-231 sodium.
    FAM labled GEM-231 sodium
  • HY-D2009
    ATTO 565 iodacetamid
    ATTO 565 iodacetamid is an iodoacetamide derivative of ATTO 565 with maximum excitation/emission wavelengths: 564/590 nm.
    ATTO 565 iodacetamid
  • HY-D1111
    TFAX 568, SE
    TFAX 568, SE is an orange fluorescent dye and exhibits pH-insensitivity over a very broad range (pH in the 4-10). TFAX 568, SE yields exceptionally bright, photostable conjugates with proteins or antibodies (such as goat anti-mouse IgG).
    TFAX 568, SE
  • HY-D1219
    Disperse blue 359
    Disperse blue 359 is a blue dye commonly used for fiber dyeing.
    Disperse blue 359
  • HY-NP164I
    Concanavalin A-AF546
    Concanavalin A-AF546 (Con A-AF546) is an AF546-labled Concanavalin A (HY-P2149). Concanavalin A is a Ca2+/Mn2+-dependent and mannose/glucose-binding plant lectin. Concanavalin A binds the N- and O-glycosylated proteins of head and neck carcinoma cells glycoproteins.
    Concanavalin A-AF546
  • HY-D1074
    DiOC3(3)
    DiOC3(3) (3,3'-Dipropyloxacarbocyanine iodide) is a green fluorescent lipophilic dye with cell membrane permeability. DiOC3(3) can be used to stain cell membranes and other lipid-soluble biological structures.
    DiOC3(3)
  • HY-D2949
    SNAP-549
    SNAP-549 is a DY-549P1-labeled SNAP tag fluorescent probe, specifically designed for single-molecule imaging and dynamic tracking of proteins in living cells. SNAP-549 only labels SNAP-tag fusion proteins, with low background signals and forming irreversible connections, making it suitable for long-term observation.
    SNAP-549
  • HY-174870
    PROTAC ERα Degrader-11
    PROTAC ERα Degrader-11 is a selective and intrinsically fluorescent (Ex: 366 nm, Em: 440 nm) ERα PROTAC degrader. PROTAC ERα Degrader-11 shows good antiproliferative activity, selective ERα degradation and imaging capabilities in MCF-7 breast cancer cell lines. PROTAC ERα Degrader-11 induces G2/M phase arrest and induces apoptosis in MCF-7 cells. PROTAC ERα Degrader-11 is well-tolerated up to a dose of 500 mg/ kg with no acute toxicity in athymic nude mice. PROTAC ERα Degrader-11 can be used for the study of breast cancer.(Pink: ERα ligand (HY-167701), Blue: CRBN Ligand (HY-150831), Black: Linker, E3 ligase ligand-linker conjugate (HY-174880)).
    PROTAC ERα Degrader-11
Cat. No. Product Name / Synonyms Application Reactivity