2. Signaling Pathways
  3. GPCR/G Protein
  4. ICMT

ICMT

Isoprenylcysteine carboxyl methyltransferase

ICMT (Isoprenylcysteine carboxyl methyltransferase) is an enzyme involved in complex post-translational modification processes and plays a key role in the post-translational regulation of prenylated proteins. ICMT primarily catalyzes the methylation of post-translationally isoprene-methylated C-terminal cysteine residues and targets these proteins to the cell membrane. This modification provides the substrate protein with a hydrophobic uncharged C terminus, thereby enhancing interaction with biological membranes and/or altering the ability to interact with protein partners. ICMT-catalyzed protein prenylation may play a role in cancer. Examples include ICMT-modified RHO GTPases or Ras family members. When the ICMT gene is knocked out, it can inhibit KRAS-induced embryonic fibroblast transformation and inhibit RAS-driven tumorigenesis; or ICMT inhibition can hinder RHO GTPase-related cancer cell invasiveness and metastasis[1][2].

ICMT Related Products (66):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-157097
    ICMT-IN-10
    		Inhibitor
    ICMT-IN-10 (compound 32) is an inhibitor of ICMT (IC50=0.184 μM).
    ICMT-IN-10
  • HY-157101
    ICMT-IN-25
    		Inhibitor
    ICMT-IN-25 (compound 37) is an inhibitor of ICMT (IC50=0.025 μM).
    ICMT-IN-25
  • HY-149729
    ICMT-IN-53
    		Inhibitor
    ICMT-IN-53 (compound 12) is an ICMT inhibitor (IC50=0.96 μM) with PAMPA permeability and antiproliferative activity. ICMT-IN-53 inhibits the proliferation of MDA-MB-231 and PC3 with IC50s of 5.14 μM and 5.88 μM, respectively.
    ICMT-IN-53
  • HY-157116
    ICMT-IN-48
    		Inhibitor
    ICMT-IN-48 (compound 1) is an ICMT inhibitor that is competitive (Km=13 μM) for the prenylated methyl acceptor, the first substrate of ICMT. ICMT-IN-48 inhibits ICMT activity with IC50s affected by the concentration of the second substrate S-adenosylmethinine (SAM), and the IC50s are 3.5 μM (1×Km SAM) and 2.3 μM (10×Km SAM), respectively.
    ICMT-IN-48
  • HY-157113
    ICMT-IN-45
    		Inhibitor
    ICMT-IN-45 (compound 24) is an inhibitor of ICMT (IC50=0.132 μM).
    ICMT-IN-45
  • HY-155418
    ICMT-IN-2
    		Inhibitor
    ICMT-IN-2 (compound 45) is an inhibitor of ICMT (IC50=0.168 μM).
    ICMT-IN-2
  • HY-155423
    ICMT-IN-14
    		Inhibitor
    ICMT-IN-14 (compound 50) is an inhibitor of ICMT (IC50=0.025 μM).
    ICMT-IN-14
  • HY-157115
    ICMT-IN-47
    		Inhibitor
    ICMT-IN-47 (compound 26) is an inhibitor of ICMT (IC50=0.76 μM).
    ICMT-IN-47
  • HY-155426
    ICMT-IN-19
    		Inhibitor
    ICMT-IN-19 (compound 53) is an inhibitor of ICMT (IC50=0.026 μM).
    ICMT-IN-19
  • HY-155428
    ICMT-IN-22
    		Inhibitor
    ICMT-IN-22 (compound 62) is an inhibitor of ICMT (IC50=0.63 μM).
    ICMT-IN-22
  • HY-157117
    ICMT-IN-49
    		Inhibitor
    ICMT-IN-49 (compound 2) is an inhibitor of ICMT (IC50=0.12 μM).
    ICMT-IN-49
  • HY-157110
    ICMT-IN-42
    		Inhibitor
    ICMT-IN-42 (compound 21) is an inhibitor of ICMT (IC50=0.054 μM).
    ICMT-IN-42
  • HY-155420
    ICMT-IN-9
    		Inhibitor
    ICMT-IN-9 (compound 47) is an inhibitor of ICMT (IC50=0.16 μM).
    ICMT-IN-9
  • HY-157092
    ICMT-IN-3
    		Inhibitor
    ICMT-IN-3 (compound 27) is an inhibitor of ICMT (IC50=0.015 μM).
    ICMT-IN-3
  • HY-157094
    ICMT-IN-4
    		Inhibitor
    ICMT-IN-4 (compound 28) is an inhibitor of ICMT (IC50=0.27 μM).
    ICMT-IN-4
  • HY-149709
    ICMT-IN-35
    		Inhibitor
    ICMT-IN-35 (compound 10n) is a FTPA-triazole compound and ICMT inhibitor (IC50=0.8 μM). ICMT-IN-35 is taken up by mammalian cells and can prevent K-Ras membrane localization and induce K-Ras mislocalization. Furthermore, ICMT-IN-35 is selectively cytotoxic against ICMT+/+ MEF cells and has low micromolar activity (IC50=0.8 μM) against metastatic pancreatic cancer cell lines.
    ICMT-IN-35
  • HY-155436
    ICMT-IN-33
    		Inhibitor
    ICMT-IN-33 (compound 73) is an inhibitor of ICMT (IC50=0.46 μM).
    ICMT-IN-33
  • HY-149715
    R1-11
    		Inhibitor
    R1-11 is an indole ICMT inhibitor with an IC50 of 0.6 μM and has anticancer activity. R1-11 inhibits MDA-MB231 and PC3 cells with IC50s of 2.2 μM and 2.0 μM, respectively.
    R1-11
  • HY-149711
    Farnesylcysteine
    		Inhibitor
    Farnesylcysteine (FC) is a competitive inhibitor of ICMT. The fcly mutant has quantitatively low farnesylcysteine (FC) lyase activity and an enhanced response to ABA. Farnesylcysteine induces an ABA hypersensitive phenotype in Arabidopsis thaliana.
    Farnesylcysteine
  • HY-157206
    ICMT-IN-55
    		Inhibitor
    ICMT-IN-55 (compound 31) is an ICMT inhibitor with IC50=90 nM.
    ICMT-IN-55