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Cat. No.: HY-149715

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R1-11

R1-11 is an indole ICMT inhibitor with an IC₅₀ of 0.6 μM and has anticancer activity. R1-11 inhibits MDA-MB231 and PC3 cells with IC₅₀s of 2.2 μM and 2.0 μM, respectively.

For research use only. We do not sell to patients.

Formula: C₂₅H₃₇N₅
Molecular Weight:407.59

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

R1-11 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

R1-11 is an indole ICMT inhibitor with an IC₅₀ of 0.6 μM and has anticancer activity. R1-11 inhibits MDA-MB231 and PC3 cells with IC₅₀s of 2.2 μM and 2.0 μM, respectively^[1].

Chemical Information

Molecular Weight 407.59
Formula C₂₅H₃₇N₅
SMILES

CCCCCCCCN1C(CN(CC)CC)=CC2=CC(C3=CN=C(N)N=C3)=CC=C12
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yang WS et al. Isoprenyl carboxyl methyltransferase inhibitors: a brief review including recent patents. Amino Acids. 2017 Sep;49(9):1469-1485. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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