Isotope-Labeled Compounds

Isotope-labeled compounds are chemical substances in which some atoms in their molecules are replaced by isotope atoms. The range of stable isotope products can cover from gases to complex molecules. Isotope-labeled compounds could provide a site-specific investigation of structures, making molecules easily detectable by mass spectrometry and NMR, and maintaining the physico-chemical properties of the target molecule at the same time. MCE isotope-labeled compounds are all stable isotope-labeled compounds and are non-radioactive labeled substances. MCE isotope-labeled compounds are unique tools for identifying and understanding biological and chemical processes. Stable isotope-labeled products are now getting more and more popular among scientists. The scope of application is gradually penetrating into various scientific fields, such as life sciences, food and medicine, agriculture, environment, geology, etc. Stable isotope-labeled compounds have a wide range of applications in the Life Science areas, such as Metabolomics, Proteomics, Clinical studies, Deuterium drugs, etc.

Isotope-Labeled Compounds Inhibitors (4)

Isotope-Labeled Compounds Related Products (10876):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-Y1806S1

1,3-Dibromopropane-d₆
1,3-Dibromopropane-d₆ (Trimethylene dibromide-d₆) is the deuterium labeled 1,3-Dibromopropane (HY-Y1806). 1,3-Dibromopropane (Trimethylene dibromide) is a standard substrate. 1,3-Dibromopropane can be used for haloalkane dehalogenase DmmA assays.

HY-Y1150S2

Pivalic acid-d₉		98.00%
Pivalic acid-d₉ is the deuterium labeled Pivalic acid.

HY-108226S1

Regorafenib N-oxide and N-desmethyl (M5)-¹³C₆
Regorafenib N-oxide and N-desmethyl (M5)-¹³C₆ is the ¹³C-labeled Regorafenib N-oxide and N-desmethyl (M5).

HY-W777456

Phenanthrene-¹³C₆		99.9%
Phenanthrene-¹³C₆ is the ¹³C labeled Phenanthrene (HY-B1727). Phenanthrene is an orally active polycyclic aromatic hydrocarbon (PAH) that induces inflammation, oxidative stress, and apoptosis. Additionally, phenanthrene is commonly used to detect or assess PAH pollution in the environment.

HY-W012934S

1-Ethylpyrrolidin-2-one-d₅
1-Ethylpyrrolidin-2-one-d₅ (N-Ethyl-pyrrolidone-d₅) is deuterium labeled 1-Ethylpyrrolidin-2-one.

HY-B1901S

Eperisone-d₁₀ hydrochloride
Eperisone-d₁₀ (hydrochloride) is the deuterium labeled Eperisone hydrochloride. Eperisone Hydrochloride ((±)-Eperisone hydrochloride) is an antispastic agent used for treatment of diseases characterized by muscle stiffness and pain. It works by relaxing both skeletal muscles and vascularsmooth muscles, thus demonstrating avariety of effects such as reduction ofmyotonia, improvement of circulationand suppression of the pain reflex. Eperisone Hydrochloride ((±)-Eperisone hydrochloride) is a centrally acting muscle relaxant inhibiting the pain reflex pathway, having a vasodilator effect[2 .

HY-19655S

Cethromycin-d₆
Cethromycin-d₆ (ABT-773-d₆; Abbott-195773-d₆; A-195773-d₆) is deuterium-labeled Cethromycin (HY-19655).

HY-W032349S

1,2-Propylene-d₆ carbonate		98.65%
1,2-Propylene-d₆ carbonate is the deuterium labeled 1,2-Propylene carbonate.

HY-132187S1

Sphingosylphosphorylcholine-d₇		99.90%
Sphingosylphosphorylcholine-d₇ is the deuterium labeled Sphingosylphosphorylcholine (HY-132187).

HY-114464S

11-Beta-hydroxyandrostenedione-d₄		98.3%
11-Beta-hydroxyandrostenedione-d₄ is the deuterium labeled 11-Beta-hydroxyandrostenedione. 11-Beta-hydroxyandrostenedione (4-Androsten-11β-ol-3,17-dione) is a steroid mainly found in the the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue). 11-Beta-hydroxyandrostenedione is a 11β-hydroxysteroid dehydrogenase (11βHSD) isozymes inhibitor.

HY-W019817S1

4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol-d₃		98.49%
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol-d₃ is the deuterium labeled 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (HY-W019817). 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) is the main metabolite of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco-specific lung carcinogen. The oxidative metabolic pathway in which NNAL is oxidized to NNK and other products exhibits carcinogenic activity. 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol can be used in research on carcinogenic mechanisms related to lung cancer.

HY-N6685S1

3-Acetyldeoxynivalenol-¹³C₁₇		99.0%
3-Acetyldeoxynivalenol (3-AcDON; 3ADON)-¹³C₁₇ is the ¹³C labeled 3-Acetyldeoxynivalenol (HY-N6685). 3-Acetyldeoxynivalenol, a trichothecene mycotoxin deoxynivalenol (DON) acetylated derivative, is a brain-penetrant Fusarium mycotoxin. 3-Acetyldeoxynivalenol induces mRNA expression and production of inflammatory chemokine IL-8 in intestinal cells.

HY-130569S

7-Hydroxymethotrexate-d₃ sodium
7-Hydroxymethotrexate-d₃ (sodium) is deuterium labeled 7-Hydroxymethotrexate. 7-Hydroxymethotrexate is a major metabolite of Methotrexate (HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis.

HY-W739949

Imidaprilat-d₃
Imidaprilat-d₃ (6366A-d₃) is deuterium labeled Imidaprilate. Imidaprilate is an active metabolite of TA-6366, acts as a potent angiotensin converting enzyme (ACE) inhibitor, with an IC₅₀ of 2.6 nM, and is used in the research of hypertensive disease.

HY-W654020

Propyl paraben-¹³C₆		99.99%
Propyl paraben-¹³C₆ (Propyl parahydroxybenzoate-¹³C₆) is ¹³C labeled Propylparaben. Propylparaben (Propyl parahydroxybenzoate) is an antibacterial preservative that can be produced by plants and bacteria. Propylparaben is commonly used in cosmetics, pharmaceuticals and foods. Propylparaben disrupts follicular growth and steroidogenic function by altering cell cycle, apoptosis and steroidogenic pathways. Propylparaben also reduced sperm count and motility in rats.

HY-70037AS

Cinacalcet-d₃ hydrochloride
Cinacalcet-d₃ (hydrochloride) is the deuterium labeled Cinacalcet (hydrochloride). Cinacalcet hydrochloride (AMG-073 hydrochloride) is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease treatment.

HY-159191S

VQPGQN(Phe-¹³C₉,¹⁵N)HMFTKEKLEEVIKDI TFA
VQPGQN(Phe-¹³C9,¹⁵N)HMFTKEKLEEVIKDI (TFA) is the ¹³C and ¹⁵N labeled isotope of VQPGQN-HMFTKEKLEEVIKDI (TFA).

HY-Y0127S

D(-)-2-Aminobutyric acid-d₆		99.75%
D(-)-2-Aminobutyric acid-d₆ is the deuterium labeled D(-)-2-Aminobutyric acid. D(-)-2-Aminobutyric acid is a substrate of D-amino acid oxidase.

HY-W714951S

β-D-GlcUA-Bezafibrate-d₆
β-D-GlcUA-Bezafibrate-d6 is the deuterium labeled isotope of β-D-GlcUA-Bezafibrate.

HY-B1619S

Cromolyn-d₅
Cromolyn-d₅ (Cromoglycate-d₅) is the deuterium labeled Cromolyn (HY-B1619). Cromolyn (Cromoglycate) is an orally active GSK-3β inhibitor with an IC₅₀ of 2.0 μM. Cromolyn is also a mast cell stabilizer that can inhibit the release of mediators from mast cells, regulate reflex bronchoconstriction, and reduce non-specific bronchial hyperreactivity, and Cromolyn can be used in the research of bronchial asthma. In addition, Cromolyn has multiple activities such as anti-inflammatory, anti-allergic, anti-histamine, anti-cancer, and neuroprotective effects.

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