Cinacalcet-d3 hydrochloride
Based on 1 Customer Validation
Cinacalcet-d3 (hydrochloride) is the deuterium labeled Cinacalcet (hydrochloride). Cinacalcet hydrochloride (AMG-073 hydrochloride) is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease treatment.
For research use only. We do not sell to patients.
- Purity: 97.63%
- CAS No.: 2749807-20-1
- Formula: C22H20D3ClF3N
- Molecular Weight:396.89
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Storage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 2749807-20-1
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Unlabeled Cas 364782-34-3
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Appearance Solid
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Molecular Weight 396.89
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Formula C22H20D3ClF3N
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Color White to off-white
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SMILES
FC(F)(C1=CC(CCCN[C@@H](C2=C3C=CC=CC3=CC=C2)C([2H])([2H])[2H])=CC=C1)F.Cl
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Synonyms
AMG 073-d3 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 50 mg/mL (125.98 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Colloton M, et al. Cinacalcet HCl attenuates parathyroid hyperplasia in a rat model of secondary hyperparathyroidism. Kidney Int. 2005 Feb;67(2):467-76.;D.A. Bushinsky, et al. Effect of cinacalcet on urine calcium excretion and supersaturation in genetic hypercalciuric stone-forming rats. Kidney Int. 2006 May;69(9):1586-92. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5196 mL | 12.5979 mL | 25.1959 mL | 62.9897 mL |
| 5 mM | 0.5039 mL | 2.5196 mL | 5.0392 mL | 12.5979 mL | |
| 10 mM | 0.2520 mL | 1.2598 mL | 2.5196 mL | 6.2990 mL | |
| 15 mM | 0.1680 mL | 0.8399 mL | 1.6797 mL | 4.1993 mL | |
| 20 mM | 0.1260 mL | 0.6299 mL | 1.2598 mL | 3.1495 mL | |
| 25 mM | 0.1008 mL | 0.5039 mL | 1.0078 mL | 2.5196 mL | |
| 30 mM | 0.0840 mL | 0.4199 mL | 0.8399 mL | 2.0997 mL | |
| 40 mM | 0.0630 mL | 0.3149 mL | 0.6299 mL | 1.5747 mL | |
| 50 mM | 0.0504 mL | 0.2520 mL | 0.5039 mL | 1.2598 mL | |
| 60 mM | 0.0420 mL | 0.2100 mL | 0.4199 mL | 1.0498 mL | |
| 80 mM | 0.0315 mL | 0.1575 mL | 0.3149 mL | 0.7874 mL | |
| 100 mM | 0.0252 mL | 0.1260 mL | 0.2520 mL | 0.6299 mL |
Cinacalcet-d3 hydrochloride Related Classifications
HY-70037AS Related Classifications
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