WDR5
WD repeat protein-5; WD40 repeat domain protein 5
WDR5 is a highly conserved WD40 repeat-containing protein that is essential for proper regulation of multiple cellular processes. WDR5 is best characterized as a core scaffolding component of histone methyltransferase complexes. WDR5 also plays a crucial role in mediating protein-protein interactions that sustain oncogenesis in human cancers. One prominent example is the interaction between the transcription factor MYC and WDR5, which is essential for oncogenic processes.
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WDR5 Related Products (60)
Related Products (60)
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Antibodies (1)
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XF056-132 free base
0 ImagesCat. No.: HY-150400CAS No.: 2407450-73-9Synonyms: MS132NXF056-132 free base (MS132N) is an inactive WDR5 PROTAC degrader with a Kd value of 106 nM against human targets, and exhibits no significant binding to the VHL complex, serves as a negative control for MS132. XF056-132 free base binds to WDR5, does not induce WDR5 degradation in pancreatic cancer cells, and exerts no inhibitory effect on adenocarcinoma cells. XF056-132 free base can be used in the research of pancreatic ductal adenocarcinoma.
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WDR5-IN-8
0 ImagesCat. No.: HY-161123CAS No.: 3033259-97-8WDR5-IN-8 is a WDR5 inhibitor with IC50 value of 15.5 nM. WDR5-IN-8 shows good anti-proliferative activity in two human acute leukemia cell lines. WDR5-IN-8 has antitumor activity.
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DC_M5_2
0 ImagesCat. No.: HY-183959CAS No.: 713099-37-7
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WDR5 ligand 4
0 ImagesCat. No.: HY-184594CAS No.: 2407457-23-0WDR5 ligand 4 is a WDR5 ligand. WDR5 ligand 4 can be used as a ligand for target protein for PROTAC in the synthesis of WDR5 PROTAC degraders. WDR5 ligand 4 can be coupled with the VHL ligand (S,R,S)-AHPC-Me (HY-112078) via linker to synthesize MS67 (HY-141796). WDR5 ligand 4 can be used in cancer research.
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CS-VIP 8
0 ImagesCat. No.: HY-P10948CS-VIP 8 is a selective allosteric WDR5 protein inhibitor (Ki= 0.008 μM). CS-VIP 8 induces conformational changes in the MLL1 complex, leading to the dissociation of MLL1 from the complex, inhibiting MLL1 histone methyltransferase activity and regulating HOX gene expression. CS-VIP 8 is promising for research of hematological diseases such as leukemia.
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DD0-2363
0 ImagesCat. No.: HY-168475DD0-2363 (Compound 32d) is a dual-target inhibitor of WDR5-MLL1/HDAC. DD0-2363 inhibits cells proliferation and induces apoptosis in acute myeloid leukemia cells. DD0-2363 has antitumor activity and can be used in the research of acute myeloid leukemia.
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WDR5-MYC-IN-2
0 ImagesCat. No.: HY-174255CAS No.: 3062125-47-4WDR5-MYC-IN-2 is an inhibitor of WDR5-MYC protein-protein interaction (PPI) with IC50 of 0.59 μM. WDR5-MYC-IN-2 can be studied in research for MYC-driven cancer and development of other effective WDR5-MYC PPI inhibitors.
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XF056-132
0 ImagesCat. No.: HY-150400ACAS No.: 2694057-55-9Synonyms: MS132N TFAXF056-132 (MS132N TFA) is an inactive WDR5 PROTAC degrader with a Kd value of 106 nM against human targets, and exhibits no significant binding to the VHL complex, serves as a negative control for MS132. XF056-132 binds to WDR5, does not induce WDR5 degradation in pancreatic cancer cells, and exerts no inhibitory effect on adenocarcinoma cells. XF056-132 can be used in the research of pancreatic ductal adenocarcinoma.
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PROTAC WDR5 degrader 1
0 ImagesCat. No.: HY-168487CAS No.: 2737222-94-3PROTAC WDR5 degrader 1 is a heterobifunctional WDR5 PROTAC degrader with a DC50 value of 53 nM and a Kd value of 18 nM, exhibiting selective WDR5 degradation activity and cell permeability. PROTAC WDR5 degrader 1 induces proliferation defects in leukemia cells, with enhanced efficacy in cells overexpressing VHL. PROTAC WDR5 degrader 1 is applicable to research related to acute myeloid leukemia.
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MM-401
0 ImagesCat. No.: HY-19554CAS No.: 1442106-10-6MM-401 is a MLL1 H3K4 methyltransferase inhibitor. MM-401 inhibits MLL1 activity (IC50 = 0.32 μM) by blocking MLL1-WDR5 interaction. MM-401 can induce cell cycle arrest, apoptosis and differentiation. MM-401 can be used for the research of MLL leukemia.
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Z88418521
0 ImagesCat. No.: HY-178752CAS No.: 1240704-07-7Z88418521 is a ligand for the WDR5-MLL1 complex. Z88418521 may help disrupt the interaction of the WDR5-MLL1 complex. Z88418521 can be used in cancer research, especially in leukemia.
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C3TD078
0 ImagesCat. No.: HY-175754C3TD078 is a WDR5 WIN site inhibitor with a Ki of 0.03 nM. C3TD078 has potent antiproliferative activity and reduces the stem-cell frequency of cancer stem cells (CSCs). C3TD078 can be used for glioblastoma (GBM) research.
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MS40
0 ImagesCat. No.: HY-148829CAS No.: 2407449-49-2MS40 is a WDR5 PROTAC degrader with a DC50 of 42 nM in MV4;11 MLL-rearranged acute myeloid leukemia (AML) cells. MS40 induces WDR5 degradation dependent on WDR5, CRBN and the proteasome, dissociates the MLL/KMT2A complex from chromatin, reduces H3K4me2 levels, degrades IKZF1/IKZF3, the novel substrates of CRBN, inhibits the transcription of WDR5/MLL and IKZF target genes, and suppresses cancer cell growth. MS40 can be used in the research of MLL-rearranged acute myeloid leukemia, breast cancer, Burkholderia infection and cystic fibrosis-associated bacterial infections.
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WDR5 ligand 2
0 ImagesCat. No.: HY-168488CAS No.: 2737222-78-3WDR5 ligand 2 is the ligand for WDR5 and can be used for synthesis of PROTAC WDR5 degrader 1 (HY-168487).
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WDR5-IN-4 TFA (Standard)
0 ImagesCat. No.: HY-111753ARCAS No.: 2749300-35-2WDR5-IN-4 TFA (Standard) is the analytical standard of WDR5-IN-4 (TFA) (HY-111753A). This product is intended for research and analytical applications. WDR5-IN-4 TFA (Compound C6) is an inhibitor of the WIN site of chromatin-associated WD repeat-containing protein 5 (WDR5), with a Kd of 0.1 nM. WDR5-IN-4 TFA displaces WDR5 from chromatin and decreases the expression of associated genes, causing translational inhibition, nucleolar stress. Anti-cancer activity.
