2. Signaling Pathways
  3. Epigenetics
  4. WDR5

WDR5

WD repeat protein-5; WD40 repeat domain protein 5

WDR5 is a highly conserved WD40 repeat-containing protein that is essential for proper regulation of multiple cellular processes. WDR5 is best characterized as a core scaffolding component of histone methyltransferase complexes. WDR5 also plays a crucial role in mediating protein-protein interactions that sustain oncogenesis in human cancers. One prominent example is the interaction between the transcription factor MYC and WDR5, which is essential for oncogenic processes.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-RS15785
    WDR5 Human Pre-designed siRNA Set A
    		Degrader

    WDR5 Human Pre-designed siRNA Set A contains three designed siRNAs for WDR5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    WDR5 Human Pre-designed siRNA Set A
  • HY-159993
    MR44397
    		Inhibitor
    MR44397 is a WD40 repeat (WDR) 5 ligand, can be used for cancer research.
    MR44397
  • HY-172196
    LH168
    LH168 is a potent and selective chemical probe for WDR5, with a SPR Kd value of 13 nM.
    LH168
  • HY-150400
    XF056-132 free base
    		Degrader
    XF056-132 free base is a potent WDR5 (WD40 repeat domain protein 5) PROTAC degrader.
    XF056-132 free base
  • HY-161123
    WDR5-IN-8
    		Inhibitor
    WDR5-IN-8 is a WDR5 inhibitor with IC50 value of 15.5 nM. WDR5-IN-8 shows good anti-proliferative activity in two human acute leukemia cell lines. WDR5-IN-8 has antitumor activity.
    WDR5-IN-8
  • HY-181972
    PROTAC WDR5 degrader 2
    		Degrader
    PROTAC WDR5 degrader 2 is a WDR5 PROTAC degrader. PROTAC WDR5 degrader 2 induces WDR5 degradation via the ubiquitin-proteasome system by forming a ternary complex with WDR5 and an E3 ligase. PROTAC WDR5 degrader 2 can be used in leukemia-related research.
    PROTAC WDR5 degrader 2
  • HY-P10948
    CS-VIP 8
    		Inhibitor
    CS-VIP 8 is a selective allosteric WDR5 protein inhibitor (Ki= 0.008 μM). CS-VIP 8 induces conformational changes in the MLL1 complex, leading to the dissociation of MLL1 from the complex, inhibiting MLL1 histone methyltransferase activity and regulating HOX gene expression. CS-VIP 8 is promising for research of hematological diseases such as leukemia.
    CS-VIP 8
  • HY-168475
    DD0-2363
    		Inhibitor
    DD0-2363 (Compound 32d) is a dual-target inhibitor of WDR5-MLL1/HDAC. DD0-2363 inhibits cells proliferation and induces apoptosis in acute myeloid leukemia cells. DD0-2363 has antitumor activity and can be used in the research of acute myeloid leukemia.
    DD0-2363
  • HY-174255
    WDR5-MYC-IN-2
    		Inhibitor
    WDR5-MYC-IN-2 is an inhibitor of WDR5-MYC protein-protein interaction (PPI) with IC50 of 0.59 μM. WDR5-MYC-IN-2 can be studied in research for MYC-driven cancer and development of other effective WDR5-MYC PPI inhibitors.
    WDR5-MYC-IN-2
  • HY-178751
    Z116334910
    		Inhibitor 99.32%
    Z116334910 is a promising WDR5-MLL1 interaction disruptor. Z116334910 can be used for the study of cancer.
    Z116334910
  • HY-150400A
    XF056-132
    		Degrader
    XF056-132 is the salt form of trifluoroacetic acid (TFA, HY-21182).
    XF056-132
  • HY-168487
    PROTAC WDR5 degrader 1
    		Inhibitor
    PROTAC WDR5 degrader 1 (compound 8g) is a PROTAC degrader targeting WDR5. PROTAC WDR5 degrader 1 is composed of a target protein ligand (red part) WDR5 ligand 2 (HY-168488), a VHL-type E3 ligase ligand (blue part) (S,R,S)-AHPC (HY-125845), and a PROTAC linker (balck part) 5-Aminovaleric acid (HY-W015878), in which the VHL ligand and the PROTAC linker form a conjugate (HY-114176A).
    PROTAC WDR5 degrader 1
  • HY-19554
    MM-401
    		Inhibitor
    MM-401 is a MLL1 H3K4 methyltransferase inhibitor. MM-401 inhibits MLL1 activity (IC50 = 0.32 μM) by blocking MLL1-WDR5 interaction. MM-401 can induce cell cycle arrest, apoptosis and differentiation. MM-401 can be used for the research of MLL leukemia.
    MM-401
  • HY-178752
    Z88418521
    		Ligand
    Z88418521 is a ligand for the WDR5-MLL1 complex. Z88418521 may help disrupt the interaction of the WDR5-MLL1 complex. Z88418521 can be used in cancer research, especially in leukemia.
    Z88418521
  • HY-175754
    C3TD078
    		Inhibitor
    C3TD078 is a WDR5 WIN site inhibitor with a Ki of 0.03  nM. C3TD078 has potent antiproliferative activity and reduces the stem-cell frequency of cancer stem cells (CSCs). C3TD078 can be used for glioblastoma (GBM) research.
    C3TD078
  • HY-148829
    MS40
    		Degrader
    MS40 is a WDR5 PROTAC degrader (Kd = 125 nM). MS40 promotes the ubiquitination and degradation of WDR5. MS40-induced WDR5 degradation leads to the dissociation of the MLL/KMT2A complex from chromatin, resulting in decreased H3K4me2 levels. MS40 can be used in the study of primary leukemia.
    MS40
  • HY-163774
    WDR5-MYC-IN-1
    		Inhibitor
    WDR5-MYC-IN-1 (compound 4o) is a potent WDR5-MYC interaction inhibitor with a Ki value of 1.0 µM. WDR5-MYC-IN-1 shows antiproliferative activity.
    WDR5-MYC-IN-1
  • HY-168488
    WDR5 ligand 2
    		Ligand
    WDR5 ligand 2 is the ligand for WDR5 and can be used for synthesis of PROTAC WDR5 degrader 1 (HY-168487).
    WDR5 ligand 2
Cat. No. Product Name / Synonyms Application Reactivity