2. Signaling Pathways
  3. Epigenetics
  4. WDR5
  5. WDR5 Degrader

WDR5 Degrader

WDR5 Degraders (11):

Cat. No. Product Name Effect Purity
  • HY-141796
    MS67
    		Degrader 99.12%
    MS67 is a potent and selective WD40 repeat domain protein 5 (WDR5) degrader with a Kd of 63 nM. MS67 is inactive against other protein methyltransferases, kinases, GPCRs, ion channels, and transporters. MS67 shows potent acticancer effects.
  • HY-181972
    PROTAC WDR5 degrader 2
    		Degrader
    PROTAC WDR5 degrader 2 is a WDR5 PROTAC degrader. PROTAC WDR5 degrader 2 induces WDR5 degradation via the ubiquitin-proteasome system by forming a ternary complex with WDR5 and an E3 ligase. PROTAC WDR5 degrader 2 can be used in leukemia-related research.
  • HY-162014
    WDR5 degrader-1
    		Degrader 98.00%
    WDR5 degrader-1 (compound 25) is a cereblon (CRBN)-recruiting WDR5 degrader. WDR5 degrader-1 selectively degraded WDR5 over the CRBN neo-substrate IKZF1.
  • HY-141797
    MS33
    		Degrader 99.38%
    MS33 is a potent WDR5 degrader, with Kds of 870 nM and 120 nM for VCB and WDR5, respectively. MS33 induces WDR5 degradation in an E3 ligase VHL, and proteasome-dependent manner. MS33 can be used for the research of acute myeloid leukemia.
  • HY-150403
    XF067-68
    		Degrader 99.56%
    XF067-68 (example 132) is a PROTAC for targeted degradation of WD40 repeat domain protein 5 (WDR5). XF067-68 can be usde for the study of WDR5-mediated diseases. (Pink: target protein ligand (HY-141799); Blue: E3 ligase ligand (HY-173627); Black: linker (HY-Y0966); E3 ligase ligand + linker: HY-176517).
  • HY-169389
    OICR41114
    		Degrader
    OICR41114 is a WDR5 PROTAC degrader with an EC50 of 40 nM. OICR41114 binds both DCAF1 and WDR5, and its binding affinity for DCAF1 is significantly enhanced in the presence of WDR5 (KD increases from 59 nM to 5 nM). OICR41114 exerts antiproliferative effects on MV4-11 cells. OICR41114 can be used for the research of acute myeloid leukemia.
  • HY-RS15789
    WDR5B Human Pre-designed siRNA Set A
    		Degrader

    WDR5B Human Pre-designed siRNA Set A contains three designed siRNAs for WDR5B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
  • HY-RS15785
    WDR5 Human Pre-designed siRNA Set A
    		Degrader

    WDR5 Human Pre-designed siRNA Set A contains three designed siRNAs for WDR5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
  • HY-150400
    XF056-132 free base
    		Degrader
    XF056-132 free base is a potent WDR5 (WD40 repeat domain protein 5) PROTAC degrader.
  • HY-150400A
    XF056-132
    		Degrader
    XF056-132 is the salt form of trifluoroacetic acid (TFA, HY-21182).
  • HY-148829
    MS40
    		Degrader
    MS40 is a WDR5 PROTAC degrader (Kd = 125 nM). MS40 promotes the ubiquitination and degradation of WDR5. MS40-induced WDR5 degradation leads to the dissociation of the MLL/KMT2A complex from chromatin, resulting in decreased H3K4me2 levels. MS40 can be used in the study of primary leukemia.