2407450-73-9

XF056-132 free base Chemical Structure
2407450-73-9

Chemical Structure

XF056-132 free base

Synonym(s): MS132N

  • CAS No.: 2407450-73-9
  • Formula:C51H57F4N9O7S
  • Molecular Weight:1016.11

IUPAC Name: (4aS,4bS,5aS,6aS,7R,8R,9aS,9bS)-7-(2-chloroacetyl)-7-hydroxy-4a,6a,8-trimethyl-5a,6,6a,7,8,9,9a,9b,10,11-decahydrocyclopenta[1,2]phenanthro[4,4a-b]oxiren-2(4aH)-one

InChIKey: OJCYPKZNPSJLGY-KQNJQULYSA-N

SMILES: O=C(C(C(C(F)(F)F)=C1)=CNC1=O)NC2=C(N3C[C@H](N([C@H](C3)C)C)C)C=CC(C4=CC(C(NCC(N[C@@H](C(C)(C)C)C(N5[C@@H](C[C@H](C5)O)C(NCC6=CC=C(C7=C(N=CS7)C)C=C6)=O)=O)=O)=O)=CC=C4F)=C2

Biological Activity: XF056-132 free base (MS132N) is an inactive WDR5 PROTAC degrader with a Kd value of 106 nM against human targets, and exhibits no significant binding to the VHL complex, serves as a negative control for MS132. XF056-132 free base binds to WDR5, does not induce WDR5 degradation in pancreatic cancer cells, and exerts no inhibitory effect on adenocarcinoma cells. XF056-132 free base can be used in the research of pancreatic ductal adenocarcinoma[1][2].

Cat. No. Product Name Purity Description Pricing
HY-150400 		XF056-132 free base XF056-132 free base (MS132N) is an inactive WDR5 PROTAC degrader with a Kd value of 106 nM against human targets, and exhibits no significant binding to the VHL complex, serves as a negative control for MS132. XF056-132 free base binds to WDR5, does not induce WDR5 degradation in pancreatic cancer cells, and exerts no inhibitory effect on adenocarcinoma cells. XF056-132 free base can be used in the research of pancreatic ductal adenocarcinoma.
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