2. Membrane Transporter/Ion Channel
  3. Na+/K+ ATPase
  4. Transdermal Peptide Disulfide

Transdermal Peptide Disulfide  (Synonyms: TD 1 Disulfide(peptide))

製品番号: HY-P1565 純度: 98.79%
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Transdermal Peptide Disulfide (TD 1 Disulfide(peptide)) is a 11-amino acid peptide, binds toNa+/K+-ATPase beta-subunit (ATP1B1), and mainly interacts with the C-terminus of ATP1B1. Transdermal Peptide Disulfide can enhance the transdermal delivery of many macromolecules.

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Transdermal Peptide Disulfide

Transdermal Peptide Disulfide 構造式

CAS 番号 : 888486-23-5

容量 価格（税別） 在庫状況 数量
1 mg $80 在庫あり
5 mg $180 在庫あり
10 mg $280 在庫あり
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Other Forms of Transdermal Peptide Disulfide:

Transdermal Peptide Disulfide 関連抗体

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製品説明

Transdermal Peptide Disulfide (TD 1 Disulfide(peptide)) is a 11-amino acid peptide, binds toNa+/K+-ATPase beta-subunit (ATP1B1), and mainly interacts with the C-terminus of ATP1B1. Transdermal Peptide Disulfide can enhance the transdermal delivery of many macromolecules[1].

体外実験

In the presence of Transdermal Peptide Disulfide, because of the specific binding of Transdermal Peptide Disulfide to ATP1B1, cells will upregulate the level of ATP1B1 to maintain function and structure; as a result, the expression of ATP1B1 increases. However, as time goes on, some Transdermal Peptide Disulfide molecules may be transported into cells by endocytosis; consequently, the expression of ATP1B1 then decreases. The interaction between Transdermal Peptide Disulfide and ATP1B1 changes not only the expression of ATP1B1, but also the localization of ATP1B1 and then the structure of the epidermal layer. This interaction can be attenuated by inhibitors or competitors, which would result in the reduced delivery of macromolecular drugs across the skin[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Transdermal Peptide Disulfide 関連抗体
分子量

1061.15

分子式

C40H64N14O16S2
CAS 番号
Appearance

Solid

Color

White to off-white

Sequence

Ala-Cys-Ser-Ser-Ser-Pro-Ser-Lys-His-Cys-Gly (Disulfide bridge:Cys2-Cys10)
Sequence Shortening

ACSSSPSKHCG (Disulfide bridge:Cys2-Cys10)
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Sealed storage, away from moisture
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

H2O : ≥ 100 mg/mL (94.24 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9424 mL 4.7119 mL 9.4237 mL
5 mM 0.1885 mL 0.9424 mL 1.8847 mL
10 mM 0.0942 mL 0.4712 mL 0.9424 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
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参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.9424 mL 4.7119 mL 9.4237 mL 23.5593 mL
5 mM 0.1885 mL 0.9424 mL 1.8847 mL 4.7119 mL
10 mM 0.0942 mL 0.4712 mL 0.9424 mL 2.3559 mL
15 mM 0.0628 mL 0.3141 mL 0.6282 mL 1.5706 mL
20 mM 0.0471 mL 0.2356 mL 0.4712 mL 1.1780 mL
25 mM 0.0377 mL 0.1885 mL 0.3769 mL 0.9424 mL
30 mM 0.0314 mL 0.1571 mL 0.3141 mL 0.7853 mL
40 mM 0.0236 mL 0.1178 mL 0.2356 mL 0.5890 mL
50 mM 0.0188 mL 0.0942 mL 0.1885 mL 0.4712 mL
60 mM 0.0157 mL 0.0785 mL 0.1571 mL 0.3927 mL
80 mM 0.0118 mL 0.0589 mL 0.1178 mL 0.2945 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Transdermal Peptide Disulfide Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Transdermal Peptide Disulfide888486-23-5TD 1 Disulfide(peptide)Na+/K+ ATPaseSodium potassium pumpInhibitorinhibitorinhibit

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Transdermal Peptide Disulfide
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