1. Membrane Transporter/Ion Channel
  2. Na+/K+ ATPase
  3. Transdermal Peptide TFA

Transdermal Peptide TFA (Synonyms: TD 1 (peptide) (TFA))

Cat. No.: HY-P1565A Purity: 98.45%
Handling Instructions

Transdermal Peptide TFA (TD 1 peptide TFA) is a 11-amino acid peptide, binds to Na+/K+-ATPase beta-subunit (ATP1B1), and mainly interacts with the C-terminus of ATP1B1. Transdermal Peptide TFA can enhance the transdermal delivery of many macromolecules.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Transdermal Peptide TFA Chemical Structure

Transdermal Peptide TFA Chemical Structure

Size Price Stock Quantity
10 mM * 1  mL in Water USD 362 In-stock
Estimated Time of Arrival: December 31
1 mg USD 80 In-stock
Estimated Time of Arrival: December 31
5 mg USD 180 In-stock
Estimated Time of Arrival: December 31
10 mg USD 280 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Transdermal Peptide TFA:

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Description

Transdermal Peptide TFA (TD 1 peptide TFA) is a 11-amino acid peptide, binds to Na+/K+-ATPase beta-subunit (ATP1B1), and mainly interacts with the C-terminus of ATP1B1. Transdermal Peptide TFA can enhance the transdermal delivery of many macromolecules[1].

In Vitro

In the presence of Transdermal Peptide, because of the specific binding of Transdermal Peptide to ATP1B1, cells will upregulate the level of ATP1B1 to maintain function and structure; as a result, the expression of ATP1B1 increases. However, as time goes on, some Transdermal Peptide molecules may be transported into cells by endocytosis; consequently, the expression of ATP1B1 then decreases. The interaction between Transdermal Peptide and ATP1B1 changes not only the expression of ATP1B1, but also the localization of ATP1B1 and then the structure of the epidermal layer. This interaction can be attenuated by inhibitors or competitors, which would result in the reduced delivery of macromolecular drugs across the skin[1].

Molecular Weight

1175.17

Formula

C₄₂H₆₅F₃N₁₄O₁₈S₂

Sequence

Ala-Cys-Ser-Ser-Ser-Pro-Ser-Lys-His-Cys-Gly (Disulfide bridge:Cys2-Cys10)

Sequence Shortening

ACSSSPSKHCG (Disulfide bridge: Cys2-Cys10)

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (85.09 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8509 mL 4.2547 mL 8.5094 mL
5 mM 0.1702 mL 0.8509 mL 1.7019 mL
10 mM 0.0851 mL 0.4255 mL 0.8509 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Transdermal PeptideTD 1 (peptide) (TFA)Na+/K+ ATPaseSodium potassium pumpInhibitorinhibitorinhibit

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Transdermal Peptide TFA
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HY-P1565A
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