1. Anti-infection
  2. Bacterial

Xanthorrhizol 

Cat. No.: HY-112657
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Xanthorrhizol, isolated from Curcuma xanthorrhiza Roxb, is a potential antibacterial agent.

For research use only. We do not sell to patients.

Xanthorrhizol Chemical Structure

Xanthorrhizol Chemical Structure

CAS No. : 30199-26-9

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  • Biological Activity

  • Technical Information

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  • References

Description

Xanthorrhizol, isolated from Curcuma xanthorrhiza Roxb, is a potential antibacterial agent.

In Vitro

Xanthorrhizol is a potential antibacterial agent from Curcuma xanthorrhiza against streptocpccus mutants[1]. SEM analysis shows that, treatment of Candida species with MIC of Xanthorrhizol affects the external morphology of these yeasts. Cells incubated in the presence of Xanthorrhizol demonstrate a greater tendency to clump compared with the control cultures. Xanthorrhizol treated C. glabrata cells shows minor abnormalities without a smooth or a slightly awkward surface. Xanthorrhizol-treated Candida cells exhibit deformation and protrusions on the cell surface, which is more clearly demonstrated with C. guilliermondii and C. parapsilosis. In general, Candida exposed to, Xanthorrhizol at concentrations 1 x MICs exhibits substantial ultrastructural abnormalities such as shape deformation, protrusion, rugged cells surface, and clumping[2].

In Vivo

Ear edema induced by the topical application of TPA is suppressed by pre-treatment with Xanthorrhizol in a doserelated manner (P<0.005). Topical application of Xanthorrhizol alone does not induce ear edema in mice. All the mice treated with 7.5 nM TPA for 19 weeks after initiation by DMBA developed an average of 15.5±2.3 skin tumors per mouse (tumor multiplicity). Pre-treatment with 2 and 6 μM Xanthorrhizol reduces tumor multiplicity to 6.9±1.1 (P<0.005) and 4.0±1.1 (P<0.005), respectively, at 19 weeks. In addition, Xanthorrhizol at 2 and 6 μM dose dependently lowers the percentage of tumor-bearing mice (tumor incidence) to 80 and 57%, respectively, at the termination of the experiments. Furthermore, the tumor multiplicity (P<0.05) and incidence are reduced in the DMBA-initiated mice that are topically treated with Xanthorrhizol for 6 weeks after the induction of papillomas with hyperplasia, mild dysplasia and moderate dysplasia by topical TPA application for 6, 18 and 24 weeks, respectively. The increased ODC expression in mouse epidermis with acute inflammation and tumor promotion induced by TPA is inhibited by pre-treatment with Xanthorrhizol in a dose-dependent manner. The topical application of Xanthorrhizol after the induction of papillomas with hyperplasia and dysplasia also potently inhibited ODC expression[3].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.5802 mL 22.9011 mL 45.8022 mL
5 mM 0.9160 mL 4.5802 mL 9.1604 mL
10 mM 0.4580 mL 2.2901 mL 4.5802 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

218.33

Formula

C₁₅H₂₂O

CAS No.

30199-26-9

SMILES

OC1=CC([[email protected]](C)CC/C=C(C)\C)=CC=C1C

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Xanthorrhizol
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Xanthorrhizol

Cat. No.: HY-112657