2. Vitamin D Related/Nuclear Receptor
  3. Thyroid Hormone Receptor
  4. TR antagonist 1

TR antagonist 1 is a high-affinity thyroid hormone receptor (TR) antagonist with IC50s of 36 and 22 nM for TRα and TRβ, respectively.

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TR antagonist 1

TR antagonist 1 構造式

CAS 番号 : 500794-88-7

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 679 在庫あり
Solution
10 mM * 1 mL in DMSO USD 679 在庫あり
Solid
1 mg $220 在庫あり
5 mg $550 在庫あり
10 mg $850 在庫あり
25 mg $1600 在庫あり
50 mg $2550 在庫あり
100 mg $3950 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Based on 4 publication(s) in Google Scholar

TR antagonist 1 関連抗体

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製品説明

TR antagonist 1 is a high-affinity thyroid hormone receptor (TR) antagonist with IC50s of 36 and 22 nM for TRα and TRβ, respectively.

IC50 & Target

IC50: 36 nM (Thyroid hormone α), 22 nM (Thyroid hormone α)[1]
Cellular Effect
Cell Line Type Value Description References
CHO IC50
32 1
Compound: 6
Activity at human TR-alpha-1 transfected in CHO K1 cells by alkaline phosphatase reporter gene assay
Activity at human TR-alpha-1 transfected in CHO K1 cells by alkaline phosphatase reporter gene assay
[PMID: 17154490]
CHO IC50
32 1
Compound: 6
Activity at human TR-alpha-1 transfected in CHO K1 cells by alkaline phosphatase reporter gene assay
Activity at human TR-alpha-1 transfected in CHO K1 cells by alkaline phosphatase reporter gene assay
[PMID: 17154490]
CHO IC50
32 1
Compound: 6
Activity at human TR-alpha-1 transfected in CHO K1 cells by alkaline phosphatase reporter gene assay
Activity at human TR-alpha-1 transfected in CHO K1 cells by alkaline phosphatase reporter gene assay
[PMID: 17154490]
CHO IC50
32 1
Compound: 6
Activity at human TR-beta-1 transfected in CHO K1 cells by alkaline phosphatase reporter gene assay
Activity at human TR-beta-1 transfected in CHO K1 cells by alkaline phosphatase reporter gene assay
[PMID: 17154490]
CHO IC50
32 1
Compound: 6
Activity at human TR-beta-1 transfected in CHO K1 cells by alkaline phosphatase reporter gene assay
Activity at human TR-beta-1 transfected in CHO K1 cells by alkaline phosphatase reporter gene assay
[PMID: 17154490]
体外実験

TR antagonist 1 displays high affinity for both thyroid hormone TRα and TRβ (IC50=36 and 22 nM, respectively). TR antagonist 1 acts as a full antagonist in the TRAFR cell assay and the IC50 32 nM for both TRAFα1 and TRAFβ1[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TR antagonist 1 関連抗体
体内実験

TR antagonist 1 treatment lowers heart rate and shows a possible trend toward an increase of low-density lipoprotein cholesterol (LDL-C) in the cholesterol fed rat model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

561.26

分子式

C25H23Br2NO4
CAS 番号
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(O)CCC1=CC(Br)=C(OC2=CC(/C=C/C3=CC=NC=C3)=C(O)C(C(C)C)=C2)C(Br)=C1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
体外: 

DMSO : 50 mg/mL (89.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7817 mL 8.9085 mL 17.8171 mL
5 mM 0.3563 mL 1.7817 mL 3.5634 mL
10 mM 0.1782 mL 0.8909 mL 1.7817 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

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体積 （開始）

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濃度 （終了）

C2

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体積 （終了）

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7817 mL 8.9085 mL 17.8171 mL 44.5426 mL
5 mM 0.3563 mL 1.7817 mL 3.5634 mL 8.9085 mL
10 mM 0.1782 mL 0.8909 mL 1.7817 mL 4.4543 mL
15 mM 0.1188 mL 0.5939 mL 1.1878 mL 2.9695 mL
20 mM 0.0891 mL 0.4454 mL 0.8909 mL 2.2271 mL
25 mM 0.0713 mL 0.3563 mL 0.7127 mL 1.7817 mL
30 mM 0.0594 mL 0.2970 mL 0.5939 mL 1.4848 mL
40 mM 0.0445 mL 0.2227 mL 0.4454 mL 1.1136 mL
50 mM 0.0356 mL 0.1782 mL 0.3563 mL 0.8909 mL
60 mM 0.0297 mL 0.1485 mL 0.2970 mL 0.7424 mL
80 mM 0.0223 mL 0.1114 mL 0.2227 mL 0.5568 mL
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TR antagonist 1 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TR antagonist 1500794-88-7TR antagonist1TR antagonist-1Thyroid Hormone ReceptorTHRInhibitorinhibitorinhibit

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製品名:
TR antagonist 1
製品番号:
HY-111443
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