2. Cell Cycle/DNA Damage
  3. Eukaryotic Initiation Factor (eIF)
  4. Fosigotifator THAM sodium

Fosigotifator THAM sodium  (Synonyms: ABBV-CLS-7262 THAM sodium)

Art. -Nr.: HY-153399A
COA
SDS
Handling Instructions Technical Support

Fosigotifator (ABBV-CLS-7262) THAM sodium is a brain penetrant, orally active EIF2b (eukaryotic initiation factor) activator. Fosigotifator THAM sodium stabilizes the elF2B complex and boosts the activity, including that of complexes carrying pathogenic vanishing white matter (VWM) mutations. Fosigotifator THAM sodium is an integrated stress response inhibitor (ISRI). Fosigotifator THAM sodium can be used for amyotrophic lateral sclerosis research.

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Fosigotifator THAM sodium

Fosigotifator THAM sodium Chemische Struktur

CAS. Nr. : 2945073-88-9

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10 mg Angebot einholen 2 - 3 weeks 1 - 2 Weeks 3 - 4 weeks 2 - 3 weeks
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Other Forms of Fosigotifator THAM sodium:

Fosigotifator THAM sodium Related Antibodies

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Beschreibung

Fosigotifator (ABBV-CLS-7262) THAM sodium is a brain penetrant, orally active EIF2b (eukaryotic initiation factor) activator. Fosigotifator THAM sodium stabilizes the elF2B complex and boosts the activity, including that of complexes carrying pathogenic vanishing white matter (VWM) mutations. Fosigotifator THAM sodium is an integrated stress response inhibitor (ISRI). Fosigotifator THAM sodium can be used for amyotrophic lateral sclerosis research[1][2].

In Vivo

Fosigotifator THAM sodium improves motor dysfunction in a VWM mouse model. Simultaneously, integrated stress response (ISR) gene expression and pharmacodynamic biomarkers also underwent corresponding changes. Furthermore, neurofilament light chain (NfL) levels are significantly reduced in VWM mice treated with Fosigotifator THAM sodium[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Klinische Studie
Molekulargewicht

782.48

Formel

C29H37Cl2F2N3NaO12P
CAS. Nr.
Appearance

Solid

Color

White to off-white

SMILES

O=C(COC(C=C1)=CC(F)=C1Cl)NC(CCC23NC(COC(C=C4)=CC(F)=C4Cl)=O)(CC2)[C@H](C3)OCO[P](O)(O[Na])=O.OCC(CO)(N)CO
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Reinheit & Dokumentation

Purity: 98.03%

SDS (252 KB)

COA (247 KB) HNMR (146 KB) LCMS (110 KB)

Handling Instructions (2659 KB)
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Fosigotifator THAM sodium Related Classifications

  • Molaritätsrechner

  • Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)

Diese Gleichung wird häufig abgekürzt als: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fosigotifator THAM2945073-88-9ABBV-CLS-7262 THAMEukaryotic Initiation Factor (eIF)ISRIamyotrophic lateral sclerosisInhibitorinhibitorinhibit

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