2945073-88-9
Chemical Structure
Fosigotifator THAM sodium
Synonym(s): ABBV-CLS-7262 THAM sodium
- CAS No.: 2945073-88-9
- Formula:C29H37Cl2F2N3NaO12P
- Molecular Weight:782.48
InChIKey: RQOVFRFZOGXABE-IPMISBIPSA-M
SMILES: O=C(COC(C=C1)=CC(F)=C1Cl)NC(CCC23NC(COC(C=C4)=CC(F)=C4Cl)=O)(CC2)[C@H](C3)OCO[P](O)(O[Na])=O.OCC(CO)(N)CO
Biological Activity: Fosigotifator (ABBV-CLS-7262) THAM sodium is a brain penetrant, orally active EIF2b (eukaryotic initiation factor) activator. Fosigotifator THAM sodium stabilizes the elF2B complex and boosts the activity, including that of complexes carrying pathogenic vanishing white matter (VWM) mutations. Fosigotifator THAM sodium is an integrated stress response inhibitor (ISRI). Fosigotifator THAM sodium can be used for amyotrophic lateral sclerosis research[1][2].
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Fosigotifator THAM sodium | Fosigotifator (ABBV-CLS-7262) THAM sodium is a brain penetrant, orally active EIF2b (eukaryotic initiation factor) activator. Fosigotifator THAM sodium stabilizes the elF2B complex and boosts the activity, including that of complexes carrying pathogenic vanishing white matter (VWM) mutations. Fosigotifator THAM sodium is an integrated stress response inhibitor (ISRI). Fosigotifator THAM sodium can be used for amyotrophic lateral sclerosis research. | |||||||||||||||||||||
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- [1]. Michael Hayden, et al. Method of treating amyotrophic lateral sclerosis with pridopidine. US20230190724 A1. 2023.6.22.
- [2]. Amos Baruch, et al. Development of eIF2B Activator ABBV-CLS-7262 as a Novel Treatment for Vanishing White Matter Disease (P2-8.001). Neurology. Volume 102 Number 7 April 09,2024
Keywords
