2. Cell Cycle/DNA Damage
  3. Eukaryotic Initiation Factor (eIF)
  4. Fosigotifator THAM sodium

Fosigotifator THAM sodium  (Synonyms: ABBV-CLS-7262 THAM sodium)

Cat. No.: HY-153399A
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Fosigotifator (ABBV-CLS-7262) THAM sodium is a brain penetrant, orally active EIF2b (eukaryotic initiation factor) activator. Fosigotifator THAM sodium stabilizes the elF2B complex and boosts the activity, including that of complexes carrying pathogenic vanishing white matter (VWM) mutations. Fosigotifator THAM sodium is an integrated stress response inhibitor (ISRI). Fosigotifator THAM sodium can be used for amyotrophic lateral sclerosis research.

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Fosigotifator THAM sodium

Fosigotifator THAM sodium Chemical Structure

CAS No. : 2945073-88-9

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10 mg Obtenir un devis 2 - 3 weeks 1 - 2 Weeks 3 - 4 weeks 2 - 3 weeks
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Fosigotifator THAM sodium Related Antibodies

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Description

Fosigotifator (ABBV-CLS-7262) THAM sodium is a brain penetrant, orally active EIF2b (eukaryotic initiation factor) activator. Fosigotifator THAM sodium stabilizes the elF2B complex and boosts the activity, including that of complexes carrying pathogenic vanishing white matter (VWM) mutations. Fosigotifator THAM sodium is an integrated stress response inhibitor (ISRI). Fosigotifator THAM sodium can be used for amyotrophic lateral sclerosis research[1][2].

In Vivo

Fosigotifator THAM sodium improves motor dysfunction in a VWM mouse model. Simultaneously, integrated stress response (ISR) gene expression and pharmacodynamic biomarkers also underwent corresponding changes. Furthermore, neurofilament light chain (NfL) levels are significantly reduced in VWM mice treated with Fosigotifator THAM sodium[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Essai clinique
Masse moléculaire

782.48

Formule

C29H37Cl2F2N3NaO12P
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(COC(C=C1)=CC(F)=C1Cl)NC(CCC23NC(COC(C=C4)=CC(F)=C4Cl)=O)(CC2)[C@H](C3)OCO[P](O)(O[Na])=O.OCC(CO)(N)CO
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Pureté et documentation
Références
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Fosigotifator THAM sodium Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fosigotifator THAM2945073-88-9ABBV-CLS-7262 THAMEukaryotic Initiation Factor (eIF)ISRIamyotrophic lateral sclerosisInhibitorinhibitorinhibit

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