2. Cell Cycle/DNA Damage
  3. Eukaryotic Initiation Factor (eIF)
  4. Fosigotifator THAM sodium

Fosigotifator THAM sodium  (Synonyms: ABBV-CLS-7262 THAM sodium)

Cat. No.: HY-153399A
COA
SDS
Instrucciones de manejo Technical Support

Fosigotifator (ABBV-CLS-7262) THAM sodium is a brain penetrant, orally active EIF2b (eukaryotic initiation factor) activator. Fosigotifator THAM sodium stabilizes the elF2B complex and boosts the activity, including that of complexes carrying pathogenic vanishing white matter (VWM) mutations. Fosigotifator THAM sodium is an integrated stress response inhibitor (ISRI). Fosigotifator THAM sodium can be used for amyotrophic lateral sclerosis research.

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Fosigotifator THAM sodium

Fosigotifator THAM sodium Estructura química

No. CAS : 2945073-88-9

Tamaño Precio Stock Cantidad
1 mg Obtener un presupuesto 2 - 3 weeks 1 - 2 Weeks 3 - 4 weeks 2 - 3 weeks
5 mg Obtener un presupuesto 2 - 3 weeks 1 - 2 Weeks 3 - 4 weeks 2 - 3 weeks
10 mg Obtener un presupuesto 2 - 3 weeks 1 - 2 Weeks 3 - 4 weeks 2 - 3 weeks
50 mg   Obtener un presupuesto  
100 mg   Obtener un presupuesto  
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Other Forms of Fosigotifator THAM sodium:

Fosigotifator THAM sodium Related Antibodies

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Descripciòn

Fosigotifator (ABBV-CLS-7262) THAM sodium is a brain penetrant, orally active EIF2b (eukaryotic initiation factor) activator. Fosigotifator THAM sodium stabilizes the elF2B complex and boosts the activity, including that of complexes carrying pathogenic vanishing white matter (VWM) mutations. Fosigotifator THAM sodium is an integrated stress response inhibitor (ISRI). Fosigotifator THAM sodium can be used for amyotrophic lateral sclerosis research[1][2].

In Vivo

Fosigotifator THAM sodium improves motor dysfunction in a VWM mouse model. Simultaneously, integrated stress response (ISR) gene expression and pharmacodynamic biomarkers also underwent corresponding changes. Furthermore, neurofilament light chain (NfL) levels are significantly reduced in VWM mice treated with Fosigotifator THAM sodium[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Ensayo clínico
Peso molecular

782.48

Fòrmula

C29H37Cl2F2N3NaO12P
No. CAS
Appearance

Solid

Color

White to off-white

SMILES

O=C(COC(C=C1)=CC(F)=C1Cl)NC(CCC23NC(COC(C=C4)=CC(F)=C4Cl)=O)(CC2)[C@H](C3)OCO[P](O)(O[Na])=O.OCC(CO)(N)CO
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Pureza y Documentación

Purity: 98.03%

SDS (252 KB)

COA (247 KB) HNMR (146 KB) LCMS (110 KB)

Instrucciones de manejo (2659 KB)
Referencias
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Fosigotifator THAM sodium Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fosigotifator THAM2945073-88-9ABBV-CLS-7262 THAMEukaryotic Initiation Factor (eIF)ISRIamyotrophic lateral sclerosisInhibitorinhibitorinhibit

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Nombre del producto:
Fosigotifator THAM sodium
Cat. No.:
HY-153399A
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