ALDH1A3-IN-1

Name: ALDH1A3-IN-1
Brand: MedChemExpress
SKU: HY-144667
Rating: 4.5 (0 reviews)

Cat. No.: HY-144667 Pureza: 98.05%: Ficha de datos
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ALDH1A3-IN-1 (Compound 14) is a potent ALDH1A3 inhibitor, with an IC₅₀ of 0.63 μM and a K_i of 0.46 μM. ALDH1A3-IN-1 can be studied in prostate cancer.

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ALDH1A3-IN-1 Estructura química

No. CAS : 1695970-90-1

Tamaño	Stock	Cantidad
Liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Liquid
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
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500 mg	Obtener un presupuesto

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Based on 1 Customer Validation

Recomendaciones destacadas

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•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas Aldehyde Dehydrogenase (ALDH):

Ver todas las isoformas

ALDH1 ALDH2 ALDH3

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Descripciòn

ALDH1A3-IN-1 (Compound 14) is a potent ALDH1A3 inhibitor, with an IC₅₀ of 0.63 μM and a K_i of 0.46 μM. ALDH1A3-IN-1 can be studied in prostate cancer^[1].

IC₅₀ & Target

ALDH1

ALDH1A3

0.63 μM (IC₅₀)

ALDH1A1

7.08 μM (IC₅₀)

ALDH3A1

8.00 μM (IC₅₀)

ALDH1A3

0.46 μM (Ki)

ALDH1A3

26.92 μM (Km)

Cellular Effect

Cell Line	Type	Value	Description	References
DU-145	IC₅₀	61 μM Compound: 14	Antiproliferative activity against human DU145 cells expressing ALDH1A1 assessed as reduction in cell survival measured after 96 hrs by MTT assay Antiproliferative activity against human DU145 cells expressing ALDH1A1 assessed as reduction in cell survival measured after 96 hrs by MTT assay	[PMID: 35212533]
LNCaP	IC₅₀	25 μM Compound: 14	Antiproliferative activity against human LNCaP cells expressing ALDH1A3 assessed as reduction in cell survival measured after 96 hrs by MTT assay Antiproliferative activity against human LNCaP cells expressing ALDH1A3 assessed as reduction in cell survival measured after 96 hrs by MTT assay	[PMID: 35212533]
PC-3	IC₅₀	47 μM Compound: 14	Antiproliferative activity against human PC-3 cells expressing ALDH1A1 and ALDH3A1 assessed as reduction in cell survival measured after 96 hrs by MTT assay Antiproliferative activity against human PC-3 cells expressing ALDH1A1 and ALDH3A1 assessed as reduction in cell survival measured after 96 hrs by MTT assay	[PMID: 35212533]

In Vitro

ALDH1A3-IN-1 (Compound 14) (0-200 μM, 96 h) shows antiproliferative activity in prostate cancer cell lines^[1].
ALDH1A3-IN-1 (0-200 μM, 72 h) reduces cell viability of primary prostate cells in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	PC3, LNCaP, and DU145 cells
Concentration:	12.5-200 µM
Incubation Time:	96 h
Result:	Showed antiproliferative activity with IC₅₀ values of 47 ± 6, 25 ± 1, and 61 ± 5 µM against PC3, LNCaP, and DU145 cells.

Cell Viability Assay^[1]

Cell Line:	Primary cells cultured at early passage from human prostate tissue biopsies
Concentration:	50 and 200 μM
Incubation Time:	72 h
Result:	Resulted a dose-dependent reduction in percentage cell viability of primary prostate epithelial cultures.

Peso molecular

284.19

Fòrmula

C₁₃H₁₈BrNO

No. CAS

1695970-90-1

Appearance

Liquid (Density: 1.284±0.06 g/cm³)

Color

Light yellow to yellow

SMILES

O=CC1=CC(Br)=C(C=C1)N(CCC)CCC

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvente y solubilidad

In Vitro:

DMSO : 100 mg/mL (351.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5188 mL	17.5939 mL	35.1877 mL
5 mM	0.7038 mL	3.5188 mL	7.0375 mL
10 mM	0.3519 mL	1.7594 mL	3.5188 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad
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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Working solution concentration: mg/mL

Pureza y Documentación

Purity: 98.05%

Select Batch:

Ficha de datos (276 KB) SDS (252 KB)

COA (252 KB) HNMR (117 KB) RP-HPLC (244 KB) MS (69 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Ali I M Ibrahim, et al. Expansion of the 4-(Diethylamino)benzaldehyde Scaffold to Explore the Impact on Aldehyde Dehydrogenase Activity and Antiproliferative Activity in Prostate Cancer. J Med Chem. 2022 Mar 10;65(5):3833-3848. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.5188 mL	17.5939 mL	35.1877 mL	87.9693 mL
	5 mM	0.7038 mL	3.5188 mL	7.0375 mL	17.5939 mL
	10 mM	0.3519 mL	1.7594 mL	3.5188 mL	8.7969 mL
	15 mM	0.2346 mL	1.1729 mL	2.3458 mL	5.8646 mL
	20 mM	0.1759 mL	0.8797 mL	1.7594 mL	4.3985 mL
	25 mM	0.1408 mL	0.7038 mL	1.4075 mL	3.5188 mL
	30 mM	0.1173 mL	0.5865 mL	1.1729 mL	2.9323 mL
	40 mM	0.0880 mL	0.4398 mL	0.8797 mL	2.1992 mL
	50 mM	0.0704 mL	0.3519 mL	0.7038 mL	1.7594 mL
	60 mM	0.0586 mL	0.2932 mL	0.5865 mL	1.4662 mL
	80 mM	0.0440 mL	0.2199 mL	0.4398 mL	1.0996 mL
	100 mM	0.0352 mL	0.1759 mL	0.3519 mL	0.8797 mL

ALDH1A3-IN-1 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ALDH1A3-IN-11695970-90-1Aldehyde Dehydrogenase (ALDH)PC3LNCaPDU145Inhibitorinhibitorinhibit

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ALDH1A3-IN-1

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ALDH1A3-IN-1 Related Antibodies

Recomendaciones destacadas

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas Aldehyde Dehydrogenase (ALDH):

Actividad biológica

Pureza y Documentación

Referencias

Revisión del cliente

ALDH1A3-IN-1 Related Antibodies

Calculadora de molaridad

Calculadora de dilución

Complete Stock Solution Preparation Table

ALDH1A3-IN-1 Related Classifications

Keywords:

Productos vistos recientemente:

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