Amphotericin A 

Amphotericin A is a tetraenic polyene antifungal agent, produced in the fermentation broth of Amphotericin B (HY-B0221). Amphotericin A has a structure identical to Amphotericin B except for a single bond between carbons 28 and 29 instead of a double bond. Amphotericin A can be used for research on fungal infection^[1][2].

Amphotericin A (0.35-0.80 μg/mL dissolved in DMSO; 3.5-10.1 μg/mL aqueous suspension) inhibits the growth of Candida albicans, Candida tropicalis, and Saccharomyces cerevisiae with MIC values ranging from 0.35 to 0.80 μg/mL when dissolved in DMSO, and 3.5 to 10.1 μg/mL when prepared as an aqueous suspension^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

926.09

C₄₇H₇₅NO₁₇

1405-32-9

C[C@@H]1OC(C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@]2(O)C[C@H](O)[C@H]([C@H](C[C@@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@H](N)[C@@H]3O)/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@H](C)[C@@H](O)[C@H]1C)O2)C(O)=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Aszalos A, et al. Physico-chemical and microbiological comparison of nystatin, amphotericin A and amphotericin B, and structure of amphotericin A. J Antibiot (Tokyo). 1985;38(12):1699-1713.

  [2]. Sowiński P, et al. The structure of amphotericin A. II. The complete structure of the antibiotic. J Antibiot (Tokyo). 1985 Feb;38(2):175-80.