Anabaseine

製品番号: HY-115766: Data Sheet SDS 取扱説明書
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Anabaseine, a brain-penetrant occurring alkaloid toxin, is potent agonist of multiple nicotinic acetylcholine receptors (AChRs). Anabaseine stimulates the neuromuscular α12β1γδ or α12β1γɛ and α7 AChRs. Anabaseine is also a weak partial agonist at α4β2 nAChRs.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Anabaseine 構造式

CAS 番号 : 3471-05-4

容量	価格（税別）	在庫状況
Liquid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	USD 33	見積もりとリードタイムを求めるのご確認
Solution
10 mM * 1 mL in Water	USD 33	見積もりとリードタイムを求めるのご確認
Liquid
5 mg	$30	見積もりとリードタイムを求めるのご確認
10 mg	$50	見積もりとリードタイムを求めるのご確認

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

Other Forms of Anabaseine:

Anabaseine-d₄ 在庫あり
Anabaseine (Standard) お問い合わせ

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生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

IC₅₀ & Target

AChRs^[1]

体外実験

Anabaseine is a full agonist at α7 AChR in the central nervous system (CNS) and a full agonist at α1β1 δ and α1β1γδ (Torpedo) in the peripheral nervous system^[1].
Anabaseine acts as neuromuscular agonist on the frog rectus abdominis muscle (EC₅₀: 0.25-0.74 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Anabaseine (3.6 μmol/kg; subcutaneous injection) elevates ACh levels in the rat prefrontal cortex^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

臨床実験

分子量

160.22

分子式

C₁₀H₁₂N₂

CAS 番号

3471-05-4

Appearance

Liquid (Density: 1.09±0.1 g/cm³)

Color

Light brown to brown

SMILES

C1(C2=CC=CN=C2)=NCCCC1

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

溶剤 & 溶解度

体外:

H₂O : ≥ 200 mg/mL (1248.28 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.2414 mL	31.2071 mL	62.4142 mL
5 mM	1.2483 mL	6.2414 mL	12.4828 mL
10 mM	0.6241 mL	3.1207 mL	6.2414 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (31.21 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

純度とドキュメンテーション

データシート (274 KB) SDS (393 KB) 取扱説明書 (2659 KB)

参考文献

[1]. Kem W, et al. The Nemertine Toxin Anabaseine and Its Derivative DMXBA (GTS-21): Chemical and Pharmacological Properties. Mar Drugs. 2006;4(3):255-273.

[2]. Summers KL et al. Nicotinic agonist modulation of neurotransmitter levels in the rat frontoparietal cortex. Jpn J Pharmacol. 1997 Jun;74(2):139-46. [Content Brief]

[3]. Andrud K, et al. Investigation of the Possible Pharmacologically Active Forms of the Nicotinic Acetylcholine Receptor Agonist Anabaseine. Mar Drugs. 2019;17(11):614. Published 2019 Oct 29. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	6.2414 mL	31.2071 mL	62.4142 mL	156.0355 mL
	5 mM	1.2483 mL	6.2414 mL	12.4828 mL	31.2071 mL
	10 mM	0.6241 mL	3.1207 mL	6.2414 mL	15.6035 mL
	15 mM	0.4161 mL	2.0805 mL	4.1609 mL	10.4024 mL
	20 mM	0.3121 mL	1.5604 mL	3.1207 mL	7.8018 mL
	25 mM	0.2497 mL	1.2483 mL	2.4966 mL	6.2414 mL
	30 mM	0.2080 mL	1.0402 mL	2.0805 mL	5.2012 mL
	40 mM	0.1560 mL	0.7802 mL	1.5604 mL	3.9009 mL
	50 mM	0.1248 mL	0.6241 mL	1.2483 mL	3.1207 mL
	60 mM	0.1040 mL	0.5201 mL	1.0402 mL	2.6006 mL
	80 mM	0.0780 mL	0.3901 mL	0.7802 mL	1.9504 mL
	100 mM	0.0624 mL	0.3121 mL	0.6241 mL	1.5604 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Anabaseine Related Classifications

Neurological Disease

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量		濃度		体積		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）	×	体積 _（開始）	=	濃度 _（終了）	×	体積 _（終了）
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anabaseine3471-05-4nAChRNicotinic acetylcholine receptorsneuromuscular receptorbraintoxicityAChRsperipheral neuromuscularnon-selectiveInhibitorinhibitorinhibit

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