2. Immunology/Inflammation
  3. CD20
  4. Anti-Mouse CD20 Antibody (MB20-11)

Anti-Mouse CD20 Antibody (MB20-11) 

Cat. No.: HY-P990806 Pureté: 98.79%
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Anti-Mouse CD20 Antibody (MB20-11) is a kind of mouse IgG2c antibody inhibitor, targeting to CD20. Anti-Mouse CD20 Antibody (MB20-11) can deplete mature B cells in lymphoid tissues. Anti-Mouse CD20 Antibody (MB20-11) can be used for the researches of cancer, immunology and metabolic Disease, such as lymphoma and diabetes.

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Anti-Mouse CD20 Antibody (MB20-11)

Anti-Mouse CD20 Antibody (MB20-11) Chemical Structure

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Description

Anti-Mouse CD20 Antibody (MB20-11) is a kind of mouse IgG2c antibody inhibitor, targeting to CD20. Anti-Mouse CD20 Antibody (MB20-11) can deplete mature B cells in lymphoid tissues. Anti-Mouse CD20 Antibody (MB20-11) can be used for the researches of cancer, immunology and metabolic Disease, such as lymphoma and diabetes[1][2][3].

Isotype

Mouse IgG2c kappa
Recommend Isotype Controls
Species Reactivity

Mouse
IC50 & Target

CD20
In Vivo

Anti-Mouse CD20 Antibody (MB20-11) (250 μg, i.v., a single dose) increases survival rate in BL3750 tumor mice models[1].
Anti-Mouse CD20 Antibody (MB20-11) (250 μg, a single dose) depletes more than 95% of mature B cells in lymphoid tissues with the effect lasting up to 8 weeks in WT mice[2].
Anti-Mouse CD20 Antibody (MB20-11) (250 μg, a single dose) suppresses tumor growth in BL3750 tumor mice models[2].
Anti-Mouse CD20 Antibody (MB20-11) (250 μg, i.v., 3 times at 2-wk intervals) depletes 90% of blood and 70% of spleen B cells in non-obese diabetic mice[3].
Anti-Mouse CD20 Antibody (MB20-11) (250 μg, i.v., 3 times at 2-wk intervals) prevents or delays the progression of type 1 diabetes in non-obese diabetic mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BL3750 tumor mice models[1]
Dosage: 250 μg
Administration: Intravenously injection
Result: Increased survival rate of mice.
Animal Model: BL3750 tumor mice models[2]
Dosage: 250 μg
Administration: /
Result: Suppressed tumor growth, with 89% of mice remaining disease free for 60 days or longer.
Reduced peritoneal B2 cell numbers.
Animal Model: Non-obese diabetic mice models[3]
Dosage: 250 μg
Administration: Intravenously injection, 3 times at 2-wk intervals
Result: Reduced circulating B cell numbers remained by 95%.
The majority of NOD mice remained diabetes free for up to 53 weeks.
Reduced the frequency of intrainsulitis and lymphocytes.
Significantly delayed diabetes onset when treated three times with CD20 mAb (weeks 15, 17, 19).
Reduces T cell proliferation.
Gene ID

12482  [NCBI]

Accession
Application

in vivo B cell depletion; Western blot
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Masse moléculaire

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse CD20 Antibody (MB20-11)]
Formulation

Please refer to the lot-specific COA for specific buffer information.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation

Purity: 98.79%

SDS (251 KB)

COA (232 KB) SDS-PAGE (128 KB) SEC-HPLC (90 KB)

Inhibitory Antibodies User Guide (603 KB)
Références
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Anti-Mouse CD20 Antibody (MB20-11) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CD20 Antibody (MB20-11)CD20B cellsCancerLymphomaBL3750DiabetesNODInhibitorinhibitorinhibit

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