Niemann Pick C1 Like 1 Antibody (YA1656)

Cat. No.: HY-P81911: Data Sheet COA
SDS
User Guide for Antibodies
FAQs
Technical Support

Niemann Pick C1 Like 1 Antibody (YA1656) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Niemann Pick C1 Like 1.

For research use only. We do not sell to patients.

Size	Stock	Quantity
20 μL	In-stock	Estimated Time of Arrival: December 31
50 μL	In-stock	Estimated Time of Arrival: December 31
100 μL	In-stock	Estimated Time of Arrival: December 31
250 μL	Get quote

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Niemann Pick C1 Like 1 Antibody (YA1656) Featured Recommendations:

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation
References

Description

Niemann Pick C1 Like 1 Antibody (YA1656) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Niemann Pick C1 Like 1.

Host

Rabbit

Clonality

Recombinant,Monoclonal

Molecular Weight

Predicted band size: 149 kDa;

Observed band size: 149 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

Q9UHC9

Gene ID

29881 [NCBI]

Immunogen

A synthesized peptide derived from human NPC1L1 aa1300-1359/1359.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:1000

Sensitivity	Endogenous	Purity	Affinity Chromatography
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in rabbit IgG in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Plays a major role in cholesterol homeostasis (PubMed:22095670). Critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte (PubMed:22095670). Involved in plant sterol absorption, it transports sitosterol, although at lower rates than cholesterol (By similarity). Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption and is approved for the treatment of hypercholesterolemia (PubMed:15928087). May have a function in the transport of multiple lipids and their homeostasis, thereby influencing lipid metabolism regulation (PubMed:15671032). May be involved in caveolin trafficking from the plasma membrane (By similarity). In addition, acts as a negative regulator of NPC2 and down-regulates its expression and secretion by inhibiting its maturation and accelerating its degradation (PubMed:22095670)

Subcellular Localization：Apical cell membrane; Multi-pass membrane protein; Cell membrane; Multi-pass membrane protein; Cytoplasmic vesicle membrane; Multi-pass membrane protein

Expression：
Tissue_specificity:Widely expressed. Expressed in liver. Also expressed in small intestine, pancreas, kidney, lung, pancreas, spleen, heart, gall bladder, brain, testis, stomach and muscle

Induction:Expression is decreased in Caco-2 cells upon PPARD activation

Isoforms & Post-Translational Modification：Q9UHC9 has 4 isomers: Q9UHC9-1: 148728 Da (predicted); Q9UHC9-2: 145794 Da (predicted); Q9UHC9-3: 79138 Da (predicted); Q9UHC9-4: 140420 Da (predicted).
Highly glycosylated

Subunit：Interacts with RAB11A, MYO5B and RAB11FIP2. Interaction with RAB11A, MYO5B and RAB11FIP2 is required for proper transport to the plasma membrane upon cholesterol depletion. Interacts with NPC2. Interacts with LIMA1 (PubMed:29880681)

Database

Entrez Gene: 29881 Human

SwissProt: Q9UHC9 Human

OMIM: 608010 Human

Research Field

Neuroscience

Synonyms

NPC1 LIKE 1; NPC1L1

Documentation

Select Batch:

Data Sheet (234 KB) SDS (251 KB)

COA (205 KB)

User Guide for Antibodies (1077 KB)

References

[1]. /biology-dictionary/a549-cell.html [Content Brief]

Niemann Pick C1 Like 1 Antibody (YA1656) Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Niemann Pick C1 Like 1 Antibody (YA1656)

Niemann Pick C1 Like 1 Antibody (YA1656) Featured Recommendations:

Product Detail

Background

Documentation

References

Niemann Pick C1 Like 1 Antibody (YA1656) Related Classifications

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