2. Anti-infection
  3. Fungal
  4. Antifungal agent 68

Antifungal agent 68 (compound 10) is an antifungal agent against Candida and Cryptococcus gattii. Antifungal agent 68 inhibits fungal ergosterol biosynthesis, possibly by targeting lanosterol 14α-demethylase (CYP51). There is an interaction between the imidazole ring of antifungal agent 68 and the heme group of CYP51.

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Antifungal agent 68

Antifungal agent 68 화학구조

CAS No. : 2925307-53-3

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Antifungal agent 68 (compound 10) is an antifungal agent against Candida and Cryptococcus gattii. Antifungal agent 68 inhibits fungal ergosterol biosynthesis, possibly by targeting lanosterol 14α-demethylase (CYP51). There is an interaction between the imidazole ring of antifungal agent 68 and the heme group of CYP51[1].

Cellular Effect
Cell Line Type Value Description References
H9c2 CC50
44.2 μM
Compound: 10
Cytotoxicity against H9c2 cells assessed as inhibition of cell proliferation incubated for 72 hrs by resazurin dye based microplate reader analysis
Cytotoxicity against H9c2 cells assessed as inhibition of cell proliferation incubated for 72 hrs by resazurin dye based microplate reader analysis
[PMID: 37146343]
분자량

414.93

화학식

C23H27ClN2O3
CAS No.
SMILES

CCCC1=CC=C(OCC(OCC2=CC=C(Cl)C=C2)CN3C=CN=C3)C(OC)=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
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Keywords:

Antifungal agent 682925307-53-3Antifungal agent68Antifungal agent-68FungalCYP-51Candida aurisCandida spp.ErgosterolEugenolNew azolesInhibitorinhibitorinhibit

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상품명:
Antifungal agent 68
Cat. No.:
HY-155710
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