2. GPCR/G Protein
  3. Apelin Receptor (APJ)
  4. Apelin-13 TFA

Apelin-13 TFA is an endogenous ligand for the G-protein coupled receptor angiotensin II protein J (APJ), activating this G protein-coupled receptor with an EC 50 value of 0.37 nM. Apelin-13 TFA has vasodilatory and antihypertensive effects. Apelin-13 TFA also can be used for researching type 2 diabetes and metabolic syndrome.

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Based on 10 publication(s) in Google Scholar

Other Forms of Apelin-13 TFA:

Apelin-13 TFA Related Antibodies

Top Publications Citing Use of Products

    Apelin-13 TFA purchased from MedChemExpress. Usage Cited in: Ren Fail. 2025 Dec;47(1):2480243.  [Abstract]

    Apelin-13 (30 μg/kg) treatment improved renal function and reduced tubulointerstitial injury. PAS staining (×200) showed histological changes in the kidneys of each group.

    Apelin-13 TFA purchased from MedChemExpress. Usage Cited in: Stem Cells Int. 2022 Mar 21;2022:3742678.  [Abstract]

    CCK-8 assay showed the cell viability of MSCs with or without Apelin-13 (0.01, 0.05, 0.1, 0.5, and 1 nM) pretreatment for 24 hours under normoxic or SD/H conditions.

    Apelin-13 TFA purchased from MedChemExpress. Usage Cited in: Stem Cells Int. 2022 Mar 21;2022:3742678.  [Abstract]

    Representative images of MitoTracker staining and quantitative analysis of the mitochondrial number and mean mitochondrial area in MSCs and Apelin-13 (0.1 nM)-pretreated MSCs under normoxic or SD/H conditions.

    Apelin-13 TFA purchased from MedChemExpress. Usage Cited in: Stem Cells Int. 2022 Mar 21;2022:3742678.  [Abstract]

    Western blotting and quantitative analysis of the protein level of Mfn1/2 and p-Drp1 ser616 in MSCs and Apelin-13-pretreated MSCs under normoxia or SD/H challenge.

    Apelin-13 TFA purchased from MedChemExpress. Usage Cited in: Stem Cells Int. 2022 Mar 21;2022:3742678.  [Abstract]

    Representative images of Annexin V/PI staining and quantitative analysis of the apoptotic rate in MSCs and Apelin-13 (0.1 nM)-pretreated MSCs under normoxic or SD/H conditions.

    • Activité biologique

    • Pureté et documentation

    • Références

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    Description

    Apelin-13 TFA is an endogenous ligand for the G-protein coupled receptor angiotensin II protein J (APJ), activating this G protein-coupled receptor with an EC 50 value of 0.37 nM. Apelin-13 TFA has vasodilatory and antihypertensive effects. Apelin-13 TFA also can be used for researching type 2 diabetes and metabolic syndrome[1][2][3].

    IC50 & Target

    IC50: 0.37 nM (APJ)[1]
    In Vivo

    Apelin-13 (200 μg/kg; IP, daily for 4 weeks) improves cardiac function, improves insulin resistance, improves lipid metabolism, significantly decreases TNF-α and leptin on serum, induces the expression of Apelin-12 in serum and markedly elevates GLUT4 and p-AMPKα2 levels[2].
    Apelin-13 (10 and 100 μM; ICV, single dosage) increases the spontaneous discharges in the majority of pallidal neurons[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Goto-Kakizaki (GK) rats (12 weeks old; 240-280 g; fed with a high-fat diet: 66.5% standard chow, 10% lard, 20% sucrose, 2.5% cholesterol and 1% pig bile salt)[2]
    Dosage: 200 µg/kg
    Administration: IP, daily for 4 weeks
    Result: Significantly decreased heart rate; lowered the levels of fasting plasma glucose (FPG), fasting insulin (FINS) and homeostasis model assessment for insulin resistancey (HOMA-IR); decreased serum levels of total cholesterol (TC), triglyceride (TG) and low density lipoprotein-cholesterol (LDL-C) and increased high density lipoprotein-cholesterol (HDL-C); decreased NO level, cNOS activity, TNF-α and leptin in serum; induced the expression of Apelin-12.
    Animal Model: Adult Wistar rats (SPF, 8-10 weeks, 240-280 g)[4]
    Dosage: 10 and 100 μM
    Administration: ICV, single dosage
    Result: Increased the spontaneous discharges in the majority of pallidal neurons.
    Masse moléculaire

    1664.85

    Formule

    C71H112F3N23O18S
    Appearance

    Solid

    Color

    White to off-white

    Sequence

    Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe
    Sequence Shortening

    QRPRLSHKGPMPF
    Livraison

    Room temperature in continental US; may vary elsewhere.
    Stockage

    Sealed storage, away from moisture

    Powder -80°C 2 years
    -20°C 1 year

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvant et solubilité
    In Vitro: 

    DMSO : ≥ 100 mg/mL (60.07 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    H2O : 50 mg/mL (30.03 mM; Need ultrasonic)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 0.6007 mL 3.0033 mL 6.0065 mL
    5 mM 0.1201 mL 0.6007 mL 1.2013 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Calculateur de molarité

    • Calculateur de dilution

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Pureté et documentation

    Purity: 97.75%

    SDS (252 KB)

    COA (258 KB) RP-HPLC (133 KB) MS (216 KB) Elemental Analysis Report (116 KB)

    Instruction de manipulation (2659 KB)
    Références

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O / DMSO 1 mM 0.6007 mL 3.0033 mL 6.0065 mL 15.0164 mL
    5 mM 0.1201 mL 0.6007 mL 1.2013 mL 3.0033 mL
    10 mM 0.0601 mL 0.3003 mL 0.6007 mL 1.5016 mL
    15 mM 0.0400 mL 0.2002 mL 0.4004 mL 1.0011 mL
    20 mM 0.0300 mL 0.1502 mL 0.3003 mL 0.7508 mL
    25 mM 0.0240 mL 0.1201 mL 0.2403 mL 0.6007 mL
    30 mM 0.0200 mL 0.1001 mL 0.2002 mL 0.5005 mL
    DMSO 40 mM 0.0150 mL 0.0751 mL 0.1502 mL 0.3754 mL
    50 mM 0.0120 mL 0.0601 mL 0.1201 mL 0.3003 mL
    60 mM 0.0100 mL 0.0501 mL 0.1001 mL 0.2503 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Apelin-13 TFA Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Apelin-13Apelin13Apelin 13Apelin Receptor (APJ)APJnervous systemsvasodilatoryantihypertensivediabetesmetabolic syndromeinsulin resistancelipidpallidal neuronsGoto-Kakizaki ratWistar ratInhibitorinhibitorinhibit

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