Art. -Nr.: HY-P1944

Apelin-13

10 Cited Publications

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Based on 10 publication(s) in Google Scholar

Apelin-13 is an endogenous ligand for the G-protein coupled receptor angiotensin II protein J (APJ), activating this G protein-coupled receptor with an EC₅₀ value of 0.37 nM. Apelin-13 is widely distributed in the central and peripheral nervous systems. Apelin-13 has vasodilatory and antihypertensive effects. Apelin-13 also can be used for researching type 2 diabetes and metabolic syndrome.

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Reinheit: 98.11%
CAS. Nr.: 217082-58-1
Formel: C₆₉H₁₁₁N₂₃O₁₆S
Molecular Weight:1550.83

Speicherung:

Sealed storage, away from moisture.

Powder -80°C, 2 years , -20°C, 1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Apelin-13 Chemical Structure

CAS. Nr.: 217082-58-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vivo
- Clinical Trial
Chemical Information
Publications (10)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

IC₅₀: 0.37 nM (APJ)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	0.87 nM Compound: Apelin-13, QRPRLSHKGPMPF	Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization	[PMID: 24755525]

In Vivo

Apelin-13 (200 µg/kg; IP, daily for 4 weeks) improves cardiac function, improves insulin resistance, improves lipid metabolism, significantly decreases TNF-α and leptin on serum, induces the expression of Apelin-12 in serum and markedly elevates GLUT4 and p-AMPKα2 levels^[2].
Apelin-13 (10 and 100 μM; ICV, single dosage) increases the spontaneous discharges in the majority of pallidal neurons^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Goto-Kakizaki (GK) rats (12 weeks old; 240-280 g; fed with a high-fat diet: 66.5% standard chow, 10% lard, 20% sucrose, 2.5% cholesterol and 1% pig bile salt)^[2]
Dosage:

200 µg/kg
Administration:

IP, daily for 4 weeks
Result:

Significantly decreased heart rate; lowered the levels of fasting plasma glucose (FPG), fasting insulin (FINS) and homeostasis model assessment for insulin resistancey (HOMA-IR); decreased serum levels of total cholesterol (TC), triglyceride (TG) and low density lipoprotein-cholesterol (LDL-C) and increased high density lipoprotein-cholesterol (HDL-C); decreased NO level, cNOS activity, TNF-α and leptin in serum; induced the expression of Apelin-12.

Animal Model:

Adult Wistar rats (SPF, 8-10 weeks, 240-280 g)^[4]
Dosage:

10 and100 μM
Administration:

ICV, single dosage
Result:

Increased the spontaneous discharges in the majority of pallidal neurons.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 217082-58-1
Appearance Solid
Molecular Weight 1550.83
Formel C₆₉H₁₁₁N₂₃O₁₆S
Color White to off-white
Sequence

Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe
Sequence Shortening

QRPRLSHKGPMPF
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (10)

All Cell Proliferation/Viability AssayHistological Imaging/StainingCell Imaging/StainingWBFlow Cytometry

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Journal Impact Factor

Signal Transduct Target Ther

COVID-19 induces new-onset insulin resistance and lipid metabolic dysregulation via regulation of secreted metabolic factors. [Abstract]

2021 Dec 16;6(1):427. PMID: 34916489
Int J Nanomedicine

Apelin-13-Loaded Macrophage Membrane-Encapsulated Nanoparticles for Targeted Ischemic Stroke Therapy via Inhibiting NLRP3 Inflammasome-Mediated Pyroptosis. [Abstract]

2024 Sep 7:19:9175-9193. PMID: 39263632
Int Immunopharmacol

Apelin-13 regulated thrombotic inflammation and induced homing of EPCs to promote the dissolution and recanalization of deep vein thrombosis. [Abstract]

2025 Dec 13:169:115969. PMID: 41391282
Biochim Biophys Acta Mol Basis Dis

The regulatory role of the apelin/APJ axis in scarring: Identification of upstream and downstream mechanisms. [Abstract]

2024 Mar 19;1870(4):167125. PMID: 38508477
Ren Fail

Apelin-13 exerts protective effects against acute kidney injury by lysosomal function regulation. [Abstract]

2025 Dec;47(1):2480243. PMID: 40125924

Apelin-13 purchased from MedChemExpress. Usage Cited in: Ren Fail. 2025 Dec;47(1):2480243. [Abstract]

Apelin-13 (30 μg/kg) treatment improved renal function and reduced tubulointerstitial injury. PAS staining (×200) showed histological changes in the kidneys of each group.
Stem Cells Int

Apelin-13 Pretreatment Promotes the Cardioprotective Effect of Mesenchymal Stem Cells against Myocardial Infarction by Improving Their Survival. [Abstract]

2022 Mar 21;2022:3742678. PMID: 35355588

Apelin-13 purchased from MedChemExpress. Usage Cited in: Stem Cells Int. 2022 Mar 21;2022:3742678. [Abstract]

CCK-8 assay showed the cell viability of MSCs with or without Apelin-13 (0.01, 0.05, 0.1, 0.5, and 1 nM) pretreatment for 24 hours under normoxic or SD/H conditions.

Apelin-13 purchased from MedChemExpress. Usage Cited in: Stem Cells Int. 2022 Mar 21;2022:3742678. [Abstract]

Representative images of MitoTracker staining and quantitative analysis of the mitochondrial number and mean mitochondrial area in MSCs and Apelin-13 (0.1 nM)-pretreated MSCs under normoxic or SD/H conditions.

Apelin-13 purchased from MedChemExpress. Usage Cited in: Stem Cells Int. 2022 Mar 21;2022:3742678. [Abstract]

Western blotting and quantitative analysis of the protein level of Mfn1/2 and p-Drp1 ser616 in MSCs and Apelin-13-pretreated MSCs under normoxia or SD/H challenge.

Apelin-13 purchased from MedChemExpress. Usage Cited in: Stem Cells Int. 2022 Mar 21;2022:3742678. [Abstract]

Representative images of Annexin V/PI staining and quantitative analysis of the apoptotic rate in MSCs and Apelin-13 (0.1 nM)-pretreated MSCs under normoxic or SD/H conditions.
Free Radic Res

Apelin deficiency exacerbates cardiac injury following infarction by accelerating cardiomyocyte ferroptosis. [Abstract]

2024 Dec 28:1-14. PMID: 39731709
Microsc Res Tech

Apelin-13 alleviates osteoclast formation and osteolysis through Nrf2-pyroptosis pathway. [Abstract]

2024 Jun;87(6):1348-1358. PMID: 38380581
SSRN

2025 Oct 9.
Ann Transl Med

Apelin receptor upregulation in spontaneously hypertensive rat contributes to the enhanced vascular smooth muscle cell proliferation by activating autophagy. [Abstract]

2021 Apr;9(8):627. PMID: 33987325

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (64.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

0.6448 mL

3.2241 mL

6.4482 mL

5 mM

0.1290 mL

0.6448 mL

1.2896 mL

10 mM

0.0645 mL

0.3224 mL

0.6448 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (280 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Tatemoto, K., Hosoya, M., Habata, Y., et al. Isolation and characterizaton of a novel endogenous peptide ligand for the human APJ receptor. Biochemical and Biophysical Research Communications 251, 471-476 (1998). [Content Brief]

[2]. Li M,et al. Apelin 13 ameliorates metabolic and cardiovascular disorders in a rat model of type 2 diabetes with a high fat diet. Mol Med Rep. 2018 Dec;18(6):5784-5790. [Content Brief]

[3]. Yamaleyeva LM, et al. Apelin-13 in blood pressure regulation and cardiovascular disease. Curr Opin Nephrol Hypertens. 2016 Sep;25(5):396-403. [Content Brief]

[4]. Wang Y, et al. Apelin-13 regulates electrical activity in the globus pallidus and induces postural changes in rats. Neural Regen Res. 2021 Nov;16(11):2264-2268. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	0.6448 mL	3.2241 mL	6.4482 mL	16.1204 mL
	5 mM	0.1290 mL	0.6448 mL	1.2896 mL	3.2241 mL
	10 mM	0.0645 mL	0.3224 mL	0.6448 mL	1.6120 mL
	15 mM	0.0430 mL	0.2149 mL	0.4299 mL	1.0747 mL
	20 mM	0.0322 mL	0.1612 mL	0.3224 mL	0.8060 mL
	25 mM	0.0258 mL	0.1290 mL	0.2579 mL	0.6448 mL
	30 mM	0.0215 mL	0.1075 mL	0.2149 mL	0.5373 mL
	40 mM	0.0161 mL	0.0806 mL	0.1612 mL	0.4030 mL
	50 mM	0.0129 mL	0.0645 mL	0.1290 mL	0.3224 mL
	60 mM	0.0107 mL	0.0537 mL	0.1075 mL	0.2687 mL

Keywords

Apelin-13

10 Cited Publications

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Apelin-13

Peptide Library

Publications Citing Use of MedChemExpress (MCE) Apelin-13

Biologische Aktivität

Chemical Information

Publications (10)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Apelin-13

Peptide Library

Publications Citing Use of MedChemExpress (MCE) Apelin-13

Biologische Aktivität

Chemical Information

Publications (10)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Apelin-13 Related Classifications

HY-P1944 Related Classifications