2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. ASP4345 free base

ASP4345 free base is a blood-brain barrier-permeable dopamine D1 receptor modulator. ASP4345 free base binds to the allosteric site of the dopamine D1 receptor, thereby enhancing dopamine activity. ASP4345 free base can be used in the research of schizophrenia and Parkinson's disease.

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ASP4345 free base

ASP4345 free base Chemische Struktur

CAS. Nr. : 1632257-75-0

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Beschreibung

ASP4345 free base is a blood-brain barrier-permeable dopamine D1 receptor modulator. ASP4345 free base binds to the allosteric site of the dopamine D1 receptor, thereby enhancing dopamine activity. ASP4345 free base can be used in the research of schizophrenia and Parkinson's disease[1].

Cellular Effect
Cell Line Type Value Description References
CHO EC50
460 1
Compound: 25
Positive allosteric modulation of human D1R expressed in CHO cells assessed as 2-fold increase in dopamine-induced cAMP accumulation preincubated for 10 mins followed by dopamine addition and measured after 20 mins by fluorescence assay
Positive allosteric modulation of human D1R expressed in CHO cells assessed as 2-fold increase in dopamine-induced cAMP accumulation preincubated for 10 mins followed by dopamine addition and measured after 20 mins by fluorescence assay
[PMID: 30525590]
Molekulargewicht

438.79

Formel

C19H14ClF3N4O3
CAS. Nr.
SMILES

O=C1OC2=CC=C(C=C2N1CC(N(CC3=NC4=C(N3)C=C(C(F)(F)F)C=C4)C)=O)Cl
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

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ASP4345 free base Related Classifications

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ASP43451632257-75-0ASP 4345ASP-4345Dopamine Receptordopamine D1 receptorsblood-brain barrierparkinson’s diseaseschizophreniadopamineInhibitorinhibitorinhibit

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