2. Cell Cycle/DNA Damage GPCR/G Protein
  3. Eukaryotic Initiation Factor (eIF) P2Y Receptor
  4. ATPγS tetralithium salt

ATPγS (tetralithium salt)  (Synonyms: Adenosine-5'-O-(3-thiotriphosphate) (tetralithium salt); Adenosine 5'-[γ-thio]triphosphate (tetralithium salt); アデノシン5'-O-(3-チオ三りん酸)(ATP-γ-S); アデノシン5'-α-チオ三りん酸)

製品番号: HY-108666 純度: 94.31%
COA 取扱説明書 Technical Support

ATPγS (tetralithium salt) is a P2Y11 receptor agonist, an antioxidant and a neuroprotective agent. ATPγS (tetralithium salt) can be used as a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor eIF4A. ATPγS (tetralithium salt) is active in ATP hydrolysis.

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CAS 番号 : 93839-89-5

容量 価格（税別） 在庫状況 数量
5 mg $198 在庫あり
10 mg $338 在庫あり
25 mg $720 在庫あり
50 mg $1250 在庫あり
100 mg $2150 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Based on 1 publication(s) in Google Scholar

Other Forms of ATPγS tetralithium salt:

ATPγS (tetralithium salt) 関連抗体

Top Publications Citing Use of Products
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In Vivo Efficacy Study

    ATPγS tetralithium salt purchased from MedChemExpress. Usage Cited in: J Adv Res. 2023 Nov:53:175-186.  [Abstract]

    ATPγS tetralithium salt (γ-ATP; 100 μM; 48 h). The expression of E-cadherin, cytokeratin-8, vimentin and α-SMA in BEAS-2B cells was measured by Western blot analysis.

    ATPγS tetralithium salt purchased from MedChemExpress. Usage Cited in: J Adv Res. 2023 Nov:53:175-186.  [Abstract]

    ATPγS tetralithium salt (γ-ATP; 100 μM; 48 h). The expression levels of E-cadherin, cytokeratin-8, vimentin and SMA were confirmed by cell immunostaining.

    ATPγS tetralithium salt purchased from MedChemExpress. Usage Cited in: J Adv Res. 2023 Nov:53:175-186.  [Abstract]

    ATPγS tetralithium salt (γ-ATP; 100 μM/mouse; intratracheal instillation). The lung injury score and lung fibrosis score were determined based on lung histological analysis with HE staining and Masson’s trichrome staining.

    ATPγS tetralithium salt purchased from MedChemExpress. Usage Cited in: J Adv Res. 2023 Nov:53:175-186.  [Abstract]

    ATPγS tetralithium salt (γ-ATP; 100 μM/mouse; intratracheal instillation). Lung tissue level of hydroxyproline on day 14.

    ATPγS tetralithium salt purchased from MedChemExpress. Usage Cited in: J Adv Res. 2023 Nov:53:175-186.  [Abstract]

    ATPγS tetralithium salt (γ-ATP; 100 μM/mouse; intratracheal instillation). The protein expression of E-cadherin, cytokeratin-8, vimentin and α-SMA was measured by Western blot analysis.

    P2Y Receptor アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    P2Y1 Receptor P2Y2 Receptor P2Y6 Receptor P2Y11 Receptor P2Y12 Receptor P2Y13 Receptor P2Y14 Receptor

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    ATPγS (tetralithium salt) is a P2Y11 receptor agonist, an antioxidant and a neuroprotective agent. ATPγS (tetralithium salt) can be used as a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor eIF4A. ATPγS (tetralithium salt) is active in ATP hydrolysis[1][2][3][4][5].

    IC50 & Target

    eIF4

     

    体外実験

    ATPγS (tetralithium salt) enhances intrinsic fluorescence and induces aggregation which increases the activity of spinach Rubisco activase[1].
    ATPγS (50-100 μM final blood concentration) attenuates inflammatory response with decreased accumulation of cells (48%, P < 0.01) and proteins (57%, P < 0.01) in bronchoalveolar lavage and reduces neutrophil infiltration and extravasation of Evans blue albumin dye into lung tissue[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    ATPγS (tetralithium salt) 関連抗体
    体内実験

    ATPγS (tetralithium salt, 50 μM final, intravenous) demonstrates preserved lung parenchymal architecture[3].
    ATPγS results in a dose-dependent effect on EBA extravasation in LPS-treated mice[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    546.98

    分子式

    C10H12Li4N5O12P3S
    CAS 番号
    Appearance

    Solid

    Color

    White to light yellow

    SMILES

    O[C@H]1[C@@H](O[C@H](COP(OP(OP(O[Li])(O[Li])=S)(O[Li])=O)(O[Li])=O)[C@H]1O)N2C3=C(C(N)=NC=N3)N=C2
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    -20°C, sealed storage, away from moisture

    *The compound is unstable in solutions, freshly prepared is recommended.
    溶剤 & 溶解度
    体外: 

    DMSO : 100 mg/mL (182.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    H2O : 75 mg/mL (137.12 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.8282 mL 9.1411 mL 18.2822 mL
    5 mM 0.3656 mL 1.8282 mL 3.6564 mL
    10 mM 0.1828 mL 0.9141 mL 1.8282 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

    ×
    体積 （開始）

    V1

    =
    濃度 （終了）

    C2

    ×
    体積 （終了）

    V2

    体内:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (4.57 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (4.57 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

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    (per animal)

    g

    Dosing volume
    (per animal)

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    純度とドキュメンテーション

    純度: ≥98.0%

    COA (250 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O / DMSO 1 mM 1.8282 mL 9.1411 mL 18.2822 mL 45.7055 mL
    5 mM 0.3656 mL 1.8282 mL 3.6564 mL 9.1411 mL
    10 mM 0.1828 mL 0.9141 mL 1.8282 mL 4.5706 mL
    15 mM 0.1219 mL 0.6094 mL 1.2188 mL 3.0470 mL
    20 mM 0.0914 mL 0.4571 mL 0.9141 mL 2.2853 mL
    25 mM 0.0731 mL 0.3656 mL 0.7313 mL 1.8282 mL
    30 mM 0.0609 mL 0.3047 mL 0.6094 mL 1.5235 mL
    40 mM 0.0457 mL 0.2285 mL 0.4571 mL 1.1426 mL
    50 mM 0.0366 mL 0.1828 mL 0.3656 mL 0.9141 mL
    60 mM 0.0305 mL 0.1524 mL 0.3047 mL 0.7618 mL
    80 mM 0.0229 mL 0.1143 mL 0.2285 mL 0.5713 mL
    100 mM 0.0183 mL 0.0914 mL 0.1828 mL 0.4571 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    ATPγS tetralithium salt Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    ATPγS tetralithium93839-89-5Adenosine-5'-O-3-thiotriphosphate tetralithium Adenosine 5'-[γ-thio]triphosphate tetralithiumEukaryotic Initiation Factor (eIF)P2Y ReceptoreIF4AEBAlungparenchymalarchitectureInhibitorinhibitorinhibit

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    製品名:
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    製品番号:
    HY-108666
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